Stimulating the aging brain with brain and sensory stimulation for language), wait

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a proof-of-concept pilot study that uses tACS and multisensory stimulation in people with Primary Progressive Aphasia to see if language-related memory can be improved. Participants undergo EEG and MRI to guide brain stimulation, plus a few brief language tasks before, during, and after stimulation across three sessions. The study compares active tACS to sham stimulation and measures verbal short-term memory performance to identify any effects and sources of variability. Results will help refine hypotheses for future trials aiming to slow language decline in PPA.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical exam supports diagnosis of PPA and/or MCI with no report of difficulty functioning in basic or instrumental activities of daily living.
* Completed clinical cognitive exam within 6 months of study baseline visit OR neuropsychological research battery within 6 months of study baseline visit.

Exclusion Criteria:

* Evidence of dementia at baseline
* Known history of neoplasm, symptomatic stroke, moderate to severe traumatic brain injury, or other significant neurologic event
* Age \<45 years.
* Evidence of severe psychiatric illness (e.g., bipolar disorder, schizophrenia).
* Presence of cardiac stimulators or pacemakers
* Any other implants near the scalp or in the eye
* Contraindications to MRI or stimulation
* Pregnancy
* History of ongoing or unmanaged seizures
* History of dyslexia or other developmental learning disabilities

Where it's running

• Medical College of Wisconsin
  Milwaukee, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Priyanka Shah-Basak, PhD — Medical College of Wisconsin
• Study coordinator: Sidney Schoenrock, MA
• Email: sschoenrock@mcw.edu
• Phone: 414-955-7579

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.