Investigating brain changes in patients with progressive apraxia of speech

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the relationship between structural and functional brain changes observed through imaging techniques and the progression of speech and language difficulties in patients diagnosed with neurodegenerative apraxia of speech (AOS). It focuses on understanding how AOS, often associated with non-fluent aphasia, manifests and evolves over time, potentially leading to cognitive impairments. The study will utilize AV-1451 as an intervention to assess these changes in a longitudinal manner, providing insights into the neurological underpinnings of the disorder.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* We will study subjects that fulfill clinical inclusion criteria for neurodegenerative AOS that have been seen and diagnosed at Mayo Clinic

Exclusion Criteria:

* Subjects with concurrent illnesses that could account for speech and language deficits, such as traumatic brain injury, strokes or developmental syndromes will be excluded.
* Women that are pregnant or post-partum and breast-feeding will be excluded. All women who can become pregnant must have a pregnancy test no more than 48 hours before the PET scan.
* Subjects will also be excluded if MRI is contraindicated (metal in head, cardiac pace maker, e.t.c.), if there is severe claustrophobia, if there are conditions that may confound brain imaging studies (e.g. structural abnormalities, including subdural hematoma or intracranial neoplasm), or if they are medically unstable or are on medications that might affect brain structure or metabolism,(e.g. chemotherapy).
* Subjects will also be excluded if they do not have an informant, or do not consent to research.

Where it's running

• Mayo Clinic
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Jennifer Whitwell, PhD — Mayo Clinic
• Study coordinator: Sarah Boland, CCRP
• Email: boland.sarah@mayo.edu
• Phone: 507-284-3863

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.