Communication Bridge: improving communication for people with primary progressive aphasia

Communication Bridge: Optimizing an evidence-based intervention for individuals with primary progressive aphasia

NIH-funded research University of Chicago · NIH-11174374

We are trying a speech and caregiver-focused program delivered by telepractice to help people living with primary progressive aphasia communicate better in everyday life.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Chicago NIH-funded
Lab location1 site (Chicago, United States)
Project IDNIH-11174374 on NIH RePORTER

What this research studies

This project refines the Communication Bridge speech-language and psychosocial program for people with primary progressive aphasia and their care partners. The team delivers the intervention remotely via telepractice and uses randomized trial methods to compare outcomes and optimize treatment stages. The program is individualized, focusing on real-world communication, social participation, and strategies for caregivers. The aim is to make benefits durable and ready for broader clinical use.

Who could benefit from this research

Good fit: Adults diagnosed with primary progressive aphasia, including cases related to Alzheimer's disease or frontotemporal degeneration, are the primary candidates for this work.

Not a fit: People without PPA or those with very advanced dementia and minimal ability to participate in communication-focused therapy are unlikely to benefit.

Why it matters

Potential benefit: If successful, this work could improve everyday communication, social participation, and quality of life for people with PPA and reduce caregiver burden.

How similar studies have performed: Earlier Communication Bridge trials (CB1 and CB2) demonstrated that telepractice delivery is feasible and produced maintained functional communication gains, so this builds on promising prior results.

Where this research is happening

Chicago, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Alzheimer disease dementiaAlzheimer syndromeAlzheimer's Disease
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.