Improving language function in patients with Primary Progressive Aphasia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to enhance language abilities in individuals diagnosed with Primary Progressive Aphasia (PPA) using non-invasive brain stimulation techniques, specifically transcranial direct current stimulation (tDCS), combined with behavioral language therapy. The approach focuses on stimulating specific brain regions that are structurally preserved but functionally impaired due to the neurodegenerative nature of PPA. By utilizing functional magnetic resonance imaging (fMRI) to identify targeted areas for stimulation, the study seeks to optimize electrode placement for each participant. The goal is to assess both short- and long-term effects of this combined intervention on language function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* diagnosed with PPA by neurologist or speech-language pathologist
* speech-language deficit arising from PPA
* native speaker of English Language or equivalent
* adequate vision (normal or corrected to normal)
* adequate hearing

Exclusion Criteria:

* meeting (Diagnostic and Statistical Manual) DSM-IV criteria for Axis I mood, anxiety, psychotic or substance abuse disorders.
* highly magnetizable metallic implants, including certain dental work
* neurological disorders besides the ones of interest for the study (e.g., epilepsy)
* Multiple Sclerosis
* Parkinson's Disease
* contraindications for MRI
* pacemakers
* metallic cardiac pumps
* valves
* magnetic materials such as surgical clips, implanted electronic perfusion pumps, or any other condition that would preclude proximity to a strong magnetic field.
* clinically significant claustrophobia
* severe systemic disease (e.g., renal failure)
* poor health
* pregnancy
* epileptic activity in the past 12 months
* family history of epilepsy or other seizure disorders
* brain surgery in the past
* metallic skull plates or implants
* skin lesions or skull damage
* excessive use of alcohol or drugs
* premorbid psychiatric disease affecting communication
* severe non-linguistic cognitive disturbances impeding language therapy

Where it's running

• University of Arizona
  Tucson, Arizona, United States Recruiting

Study contacts

• Principal investigator: Aneta Kielar, PhD — University of Arizona
• Study coordinator: Aneta Kielar, PhD
• Email: akielar@email.arizona.edu
• Phone: 15204883791

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.