Semantic rehabilitation for patients with primary progressive semantic aphasia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to evaluate the effectiveness of a personalized semantic rehabilitation protocol for patients diagnosed with primary progressive semantic aphasia (PPA). The study utilizes the Single Case Experimental Design (SCED) methodology to analyze individual responses to therapy, focusing on improving access to concepts, word memory, and meaning. Given the lack of effective pharmacological treatments for this condition, the study emphasizes the importance of tailored speech and language therapy to enhance patients' quality of life. The approach is based on previous findings that suggest personalized therapy can lead to better retention and generalization of relearned knowledge.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Have a diagnosis of primary progressive semantic aphasia according to the criteria of Gorno-Tempini et al (2011) (Appendix A)
* Being in the mild to moderate stage of dementia (MMSE score between 10 and 28) (Crum et al., 1993; Derouesné et al., 1999)
* Common French
* Being affiliated to a social security scheme
* Being over the age of 18 years old

Exclusion Criteria:

* Have significant uncorrected visual and/or hearing impairment
* Have a history of brain injuries, major head trauma
* Have untreated psychiatric disorders
* Have significant motor and/or comprehension problems that make it impossible to take part in the study
* Chronical use of drugs and/or alcohol
* Under guardians or curators
* Severe depression (Beck's depression scale score \> 9) (Beck \& al., 1961)

Where it's running

• CHU Toulouse
  Toulouse, France Recruiting

Study contacts

• Principal investigator: Jérémie PARIENTE, MD PhD — University Hospital, Toulouse
• Study coordinator: Jérémie PARIENTE, MD PhD
• Email: pariente.j@chu-toulouse.fr
• Phone: 0561777686

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.