A new catheter designed to improve complex heart procedures
Official title: Catheter for Complex Percutaneous Coronary Intervention
Funded at Crossliner INC · NIH-11011323 · Data updated 2026-11-12
This study is testing a new type of catheter designed to help doctors place stents more easily and safely in patients with severe heart artery blockages, especially when the arteries are tricky to navigate.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Crossliner INC NIH-funded |
| Lab location | 1 site (Kalamazoo, United States) |
| Project start | July 20, 2020 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $990,619 |
| NIH project number | 5R44HL152835-05 |
| Project ID | NIH-11011323 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with complex coronary artery disease requiring percutaneous coronary interventions.
✕Less likely to help
Patients with simple coronary artery disease or those who do not require stent placement may not benefit from this research.
What this research studies
This research focuses on developing a novel guide extension catheter (GEC) to enhance the delivery of stents during complex percutaneous coronary interventions (PCIs). The new catheter aims to safely navigate challenging coronary anatomies, such as calcified lesions and tortuous vessels, which are often difficult to treat with existing devices. By incorporating a microcatheter leading tip and a pre-dilatation balloon, this approach seeks to improve the success rate of stent delivery in patients with severe coronary artery disease. The study will evaluate the effectiveness and safety of this innovative catheter in real-world clinical settings.
Why it matters
Potential benefit: If successful, this research could significantly improve treatment outcomes for patients undergoing complex heart procedures.
How similar studies have gone: Previous research has shown promise in using guide extension catheters for complex cases, but this specific approach is novel and untested.
Where this research is happening
-
Crossliner INC
Kalamazoo, United States Active
Researchers
- Principal investigator: Fischell, Tim Alexander — Crossliner INC
- Study coordinator: Fischell, Tim Alexander
Related research
Other NIH-funded projects on the same topics.
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Metasurface Optical Guidewire to Treat Coronary Artery Calcification
A new optical guidewire technology aims to improve safety and effectiveness of coronary interventions in people with calcified arteries.
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Expansion of PCI use in different communities and who benefits
Aims to understand how the growth of percutaneous coronary intervention (PCI) in outpatient and inpatient settings affects disadvantaged communities differently from non-disadvantaged ones.
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Catheter that helps treat complex heart artery problems more safely
A new catheter device is being developed to help doctors deliver stents in very hard-to-treat heart artery cases, potentially making complex procedures safer and more effective.
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Catheter that helps deliver stents in tough heart arteries
A new guide-extension catheter system is being developed to safely reach and treat complex blockages in the heart’s blood vessels, especially where calcified and tortuous arteries make stent delivery hard.
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How expanding artery-opening (PCI) procedures affects disadvantaged versus other communities
This project looks at whether expanding artery-opening procedures (PCI) in hospitals and outpatient centers has helped or left behind people from disadvantaged communities with heart disease.
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Using electronic health records to identify complications after heart procedures
This study is working on a smart way to spot problems that can happen after a common heart procedure called PCI, using computer programs to look at health records, so that doctors can better keep you safe and provide the best care possible.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.