Comparing higher and lower doses of heparin for heart procedures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the effects of higher dose heparin (100 U/kg) versus lower dose heparin (70 U/kg) in patients undergoing elective percutaneous coronary intervention (PCI). It employs a multicenter, randomized, registry-based, cluster crossover design to assess outcomes such as death, myocardial infarction, and target vessel revascularization. The study aims to determine which dosing strategy is more effective in improving patient outcomes during PCI procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- Patients undergoing elective PCI

Exclusion Criteria:

* Age \<18 years
* Planned chronic total occlusion PCI
* Non-resident precluding follow up through local registries

Hospital (Cluster) Eligibility Criteria

Hospitals will be eligible to participate if they meet the following criteria:

* Submit PCI procedure data to a compatible registry that is able to provide data for the trial
* Site agrees to manage patients as per the higher or lower dose heparin policy in place during the given crossover period

Where it's running

• Hamilton Health Sciences, General Hospital
  Hamilton, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Sanjit Jolly, MD — Population Health Research Institute
• Study coordinator: Jessica Tyrwhitt
• Email: HD-PCI@phri.ca
• Phone: 905-521-2100

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.