Coronary thrombus modification to reduce microvascular damage during STEMI care

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In STEMI patients undergoing primary PCI, the trial explores whether altering the thrombus can reduce distal embolization and microvascular injury, with myocardial damage assessed by the myocardial salvage index at 3 months. The approach combines continuous and bolus thermodilution measurements before and after stent placement to quantify microvascular function and correlates these with cardiac MRI findings. The study also examines how invasive measurements relate to imaging biomarkers to improve understanding of microvascular dysfunction after reperfusion.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ST-elevation at the J-junction in a minimum of two contiguous ECG leads with a minimum of ≥ 0.1 mV in all leads, except for V2 and V3 (which required ≥ 0.2 for men ≥ 40 years old, ≥ 0.25 in men \< 40 years old, or ≥ 0.15 mV for all women) or new left bundle branch
* Admission to hospital within 12 hours of symptom debut
* Angiographic signs of a culprit lesion planned to be treated with primary percutaneous coronary intervention

Exclusion Criteria:

* Age \< 18 years or inability to provide informed consent
* Life expectancy of \< 12 months
* Hemodynamically instability
* Pregnancy or breastfeeding
* Known asthma or severe chronic obstructive pulmonary disease
* Expected inability to perform physiological measurements (due to severely tortuous arteries, ostial disease or very distal disease),
* CMR contraindications (estimated glomerular filtration rate \< 30 mL/min, magnetic or mechanically activated implants, or any prior metal implants, severe claustrophobia)
* Expected to or unavoidable to use thrombectomy

Where it's running

• Odense University Hospital
  Odense, Denmark Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.