Evaluating urinary dysfunction in patients with CANVAS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the prevalence of urinary symptoms in patients diagnosed with Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia Syndrome (CANVAS). It will evaluate the incidence of urinary dysfunction and potential complications in the urinary system among these patients. The study will involve detailed neurological examinations, laboratory tests for renal function, dysautonomia assessments, and the use of urinary function questionnaires to analyze the relationship between neurological deficits and urinary symptoms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years old and more
* genetic confirmation of CANVAS (presence of pathogenic penta nucleotide expansion in both alleles of the replication factor C subunit 1(RFC1) gene or pathological penta nucleotide expansion in the heterozygous state associated with a truncating mutation on the second allele of the RFC1 gene)
* Able to undergo renovesical ultrasound and urinary flow measurement;
* Having given informed consent in writing;
* Negative pregnancy test for people on childbearing age;
* Social security affiliated

Exclusion Criteria:

* Presenting another urological pathology of base, not related to CANVAS;
* Having undergone a urological intervention within the 6 months preceding the screening visit;
* Presenting a condition that is incompatible with the proper conduct of the study as determined by the physician;
* Protected by law under guardianship or curators, or not able to participate in a clinical study pursuant to article L. 1121-16 of the French Public Health Code
* Pregnant or breastfeeding women for women of childbearing age

Where it's running

• Nice University Hospital
  Nice, Alpes Maritimes, France Recruiting
• Montpellier University hospital
  Montpellier, Hérault, France Not yet recruiting
• Lille University Hospital
  Lille, Nord, France Not yet recruiting

Study contacts

• Study coordinator: Andra EZARU
• Email: ezaru.a@chu-nice.fr
• Phone: 04 92 03 96 55

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.