Prenyltransferase inhibitor as a new therapy for inflammatory neuropathy
Official title: Preclinical development of a prenyltransferase inhibitor to treat inflammatory neuropathy
Funded at Loyola University Chicago · NIH-11443898 · Data updated 2026-11-12
A new drug candidate called FGTI-2734 is being studied to calm nerve inflammation in conditions like AIDP/Guillain-Barré syndrome, with the goal of protecting nerves and reducing symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project start | August 21, 2026 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $342,420 |
| NIH project number | 1R61NS146354-01A1 |
| Project ID | NIH-11443898 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants would be individuals with acute inflammatory demyelinating polyneuropathy or related inflammatory neuropathies, under clinician supervision and within trial eligibility criteria.
✕Less likely to help
Patients without inflammatory neuropathies or those not meeting trial criteria may not benefit from this study.
What this research studies
This project explores a promising compound shown to dampen nerve inflammation in laboratory models. Researchers aim to move beyond statins by testing a specific prenyltransferase inhibitor, FGTI-2734, for safety and inflammatory effects on nerve tissue. The study will use lab experiments and potentially early clinical considerations to understand how this compound could reduce harmful immune activity at the nerves. If successful, it could lead to a targeted treatment for inflammatory demyelinating neuropathies that currently lack specific therapies.
Why it matters
Potential benefit: If successful, patients with inflammatory neuropathies could have a targeted option that reduces nerve inflammation and improves function.
How similar studies have gone: Preclinical work and related studies have shown anti-inflammatory effects of prenyltransferase inhibitors in nerve-related models, with translation to humans still in early stages.
Where this research is happening
-
Loyola University Chicago
Maywood, United States Active
Researchers
- Principal investigator: Langert, Kelly a — Loyola University Chicago
- Study coordinator: Langert, Kelly a
Related research
Other NIH-funded projects on the same topics.
-
Non-invasive, microscopic biomarkers to detect CIPN in chemotherapy patients
This grant aims to develop a non-invasive imaging method to measure nerve changes in patients undergoing chemotherapy to better understand and monitor chemotherapy-induced peripheral neuropathy (CIPN).
-
Neonatal Fc receptor blockade by efgartigimod to help inflammatory nerve disease
Aims to test how blocking a specific antibody trafficking receptor with efgartigimod could improve nerve inflammation in a model of AIDP/GBS-type neuropathy.
-
Schwann cell aging and secretions linked to diabetic nerve damage
A research project looking at how aging nerve cells and their secretions may drive nerve damage in people with type 2 diabetes.
-
Diabetic bladder problems in diabetes mice show sex-specific nerve and inflammation roles
Aims to understand why bladder problems happen in diabetes, exploring how inflammation and nerves differ between male and female mice.
-
KCTD11-related CMT neuropathy: uncovering how it damages nerves
We are studying a genetic form of Charcot–Marie–Tooth disease to understand what goes wrong in nerves and support future treatments.
-
Arginase-positive monocytes help protect optic nerve cells after eye injury
A study at a major university will explore how certain immune cells in the eye might protect retinal cells after traumatic injury or inflammation, aiming to turn inflammation into healing rather than damage.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.