Diabetic bladder problems in diabetes mice show sex-specific nerve and inflammation roles
Official title: Inflammation and neuropathy drive sex-specific diabetic bladder dysfunction in Akita mice
Funded at Duke University · NIH-11446046 · Data updated 2026-11-12
Aims to understand why bladder problems happen in diabetes, exploring how inflammation and nerves differ between male and female mice.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | April 15, 2019 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $700,957 |
| NIH project number | 2R01DK117890-06A1 |
| Project ID | NIH-11446046 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with adult-onset diabetes who experience urinary symptoms related to bladder dysfunction may benefit from advances arising from this work.
✕Less likely to help
Direct benefits may not be evident for individuals without diabetes or bladder symptoms.
What this research studies
This project studies diabetes-related bladder dysfunction using Akita mice and compares males and females to see how inflammation (NLRP3) and nerve changes contribute. Researchers will cross diabetic mice with NLRP3-deficient mice and examine bladder function and nerve fiber changes over time. The goal is to identify targeted interventions to prevent or treat bladder problems in people with diabetes. Results could point to sex-specific approaches for managing bladder symptoms in diabetic patients.
Why it matters
Potential benefit: Could lead to new, targeted therapies for diabetic bladder dysfunction for people with diabetes.
How similar studies have gone: Previous work has shown inflammation and neuropathy play roles in diabetic bladder dysfunction, with sex differences observed in animal models; this study aims to translate those findings further.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Purves, J. Todd — Duke University
- Study coordinator: Purves, J. Todd
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.