Understanding how a specific type of ALS spreads
Modeling the progression of SOD1-linked motor neuron disease
This research explores how a specific type of ALS, called SOD1-ALS, might spread through the body like a prion, affecting how quickly the disease progresses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10983750 on NIH RePORTER |
What this research studies
This research looks into how Amyotrophic Lateral Sclerosis (ALS), particularly the SOD1-linked form, might spread through the nervous system in a way similar to how prions cause disease. We are studying how different genetic changes in SOD1 affect the speed at which weakness spreads in patients. Our work uses special mouse models where we can introduce substances from affected mice or human patients to see how they accelerate the disease. This helps us understand the mechanisms behind the disease's progression and why some forms of ALS spread faster than others.
Who could benefit from this research
Good fit: This foundational research focuses on understanding the disease progression in patients with SOD1-linked ALS.
Not a fit: Patients without SOD1-linked ALS may not directly benefit from the specific findings of this particular research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to slow or stop the spread of ALS, especially for those with SOD1 mutations.
How similar studies have performed: The initial funding period of this award has already uncovered evidence supporting the prion-like characteristics of mutant SOD1 in accelerating paralysis in mouse models.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Chakrabarty, Paramita — University of Florida
- Study coordinator: Chakrabarty, Paramita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.