Investigating neuron dysfunction in ALS and its impact on motor control
Corticospinal Neuron Dysfunction and Degeneration in ALS: Testing the Role of Corticomotor Connectivity in Motor Neuron Disease
['FUNDING_R01'] · WINIFRED MASTERSON BURKE MED RES INST · NIH-10991312
This study is looking at how the loss of certain brain cells affects movement in people with ALS, using mice to learn more about the connections between these cells and the ones that control movement, with hopes of finding new ways to help treat the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WINIFRED MASTERSON BURKE MED RES INST (nih funded) |
| Locations | 1 site (WHITE PLAINS, UNITED STATES) |
| Trial ID | NIH-10991312 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the degeneration of corticospinal neurons (CSNs) affects motor control in patients with amyotrophic lateral sclerosis (ALS). By using mouse models, the study aims to analyze the connections between CSNs and motor neurons, which are crucial for movement. The researchers will explore how these connections form and function in ALS, with the goal of identifying potential therapeutic targets. This investigation could lead to a better understanding of the disease and inform future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with amyotrophic lateral sclerosis (ALS) or related motor neuron diseases.
Not a fit: Patients with other neurological conditions unrelated to ALS may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies that improve motor function in ALS patients.
How similar studies have performed: While this research explores a novel approach to understanding ALS, similar studies have shown promise in elucidating the role of neuronal connections in other neurodegenerative diseases.
Where this research is happening
WHITE PLAINS, UNITED STATES
- WINIFRED MASTERSON BURKE MED RES INST — WHITE PLAINS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YOSHIDA, YUTAKA — WINIFRED MASTERSON BURKE MED RES INST
- Study coordinator: YOSHIDA, YUTAKA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: advanced disease, Amyotrophic Lateral Sclerosis Motor Neuron Disease