Understanding inherited neurological disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the natural history and genetic factors of inherited neurological disorders, including various types of muscular and motor neuron diseases. Participants, both diagnosed and undiagnosed, will undergo comprehensive medical evaluations, including family history assessments and genetic testing. The study seeks to create a resource for future research and improve understanding of these rare conditions. By gathering detailed clinical data and biological samples, the research will contribute to the identification of causative mutations and potential new genes associated with these disorders.

Why it matters

Who can join: the full rules

* Participants include those with inherited neurological conditions based on the training and research needs of the Neurogenetics Branch program. There is no logical limit; however, the total number of participants that can be enrolled in the protocol will be restricted. No more than 3,500 participants with either diagnosed or undiagnosed neurological conditions and their unaffected relatives will be enrolled in this evaluation and diagnostic protocol.

INCLUSION CRITERIA:

Participants will be eligible if they:

* Have either a known or suspected, inherited neurological disease, OR are an unaffected relative (first-, second-, third, or higher degree relative) of a participant with a genetic neurological disease.
* Have the ability to understand and sign an informed consent or have a parent/legal guardian to do so if they are minor children or a legal guardian to provide consent for adults without consent capacity.
* Aged 2 years and above.

EXCLUSION CRITERIA:

Participants will not be eligible if they:

-Have a systemic disease that compromises the ability to provide adequate neurologic examination or diagnosis. An example of this would be a contagious disease that would compromise our ability to do an adequate neurological exam.

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting
• University of Mali
  Bamako, Mali Completed

Study contacts

• Principal investigator: A. Reghan Foley, M.D. — National Institute of Neurological Disorders and Stroke (NINDS)
• Study coordinator: Whitney M Spencer
• Email: whitney.spencer@nih.gov
• Phone: (301) 402-6668

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.