Understanding how motor neuron disease affects patients with Spinocerebellar Ataxia Type 1
Investigating Motor Neuron Disease in Spinocerebellar Ataxia, Type1
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-10914282
This study is looking at how nerve cells that control movement are affected in people with Spinocerebellar Ataxia Type 1 (SCA1) to better understand the disease and find new ways to help improve symptoms like muscle weakness and coordination problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10914282 on ClinicalTrials.gov |
What this research studies
This research investigates the role of motor neurons in Spinocerebellar Ataxia Type 1 (SCA1), a neurodegenerative disease that leads to progressive loss of coordination and muscle function. The study aims to uncover the molecular mechanisms behind motor neuron degeneration and its contribution to severe symptoms such as muscle weakness and respiratory failure. By examining the accumulation of toxic proteins in neurons, the research seeks to identify potential therapeutic targets that could improve patient outcomes. Patients may be involved in assessments that help clarify the relationship between motor neuron dysfunction and disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Spinocerebellar Ataxia Type 1 who experience symptoms related to motor neuron dysfunction.
Not a fit: Patients with other forms of ataxia or neurodegenerative diseases unrelated to motor neuron involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve muscle function and respiratory health in patients with SCA1.
How similar studies have performed: Previous research has shown promising results in understanding motor neuron involvement in other neurodegenerative diseases, suggesting that this approach may yield valuable insights for SCA1.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ORENGO, JAMES P — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: ORENGO, JAMES P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.