Understanding how age-related blood changes affect heart disease risk in people with HIV
Official title: Evaluation of Novel Clonal Hematopoiesis Of InDEterminate Potential, Mosaic Chromosomal Alterations and CardioVascular Disease in HIV Infection (ENCODE CVD in HIV)
Funded at University of California Los Angeles · NIH-11379983 · Data updated 2026-11-12
This study looks at whether certain blood-level genetic changes and chromosome alterations in people living with HIV relate to higher risk of heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 5, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $705,359 |
| NIH project number | 5R01HL170600-04 |
| Project ID | NIH-11379983 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults living with HIV who are aging and at risk for cardiovascular disease.
✕Less likely to help
People without HIV or those not at risk for cardiovascular disease may not benefit from these findings.
What this research studies
As HIV care improves, people live longer but face more cardiovascular issues. The research will examine clonal hematopoiesis and mosaic chromosomal alterations in blood cells of adults with HIV to see how these changes relate to heart disease risk. By analyzing blood samples and patient data, the team hopes to identify mechanisms, such as inflammatory pathways, that could be targeted to reduce cardiovascular events. The goal is to learn whether these blood changes help explain why PLWH experience more heart problems and to inform future therapies.
Why it matters
Potential benefit: If successful, findings could lead to better risk prediction and new approaches to prevent heart disease in people living with HIV.
How similar studies have gone: Previous work shows CHIP and chromosomal alterations relate to cardiovascular risk in the general population, but their role in HIV is not well understood.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Hsue, Priscilla Y. — University of California Los Angeles
- Study coordinator: Hsue, Priscilla Y.
Related research
Other NIH-funded projects on the same topics.
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Understanding how genetic changes in blood cells relate to heart disease in people with HIV
A study will look at how age-related blood cell mutations and large chromosomal changes might contribute to heart disease risk in people living with HIV.
-
Lp(a) and HIV: Understanding Heart Disease Risk in HIV Patients
This program looks at how Lipoprotein(a) contributes to higher heart disease risk in people with HIV and what Lp(a) levels mean for future treatments.
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Blood cell mutations, chromosome changes, and heart disease in people living with HIV
This project looks at whether age-related blood cell mutations and large chromosome changes help explain why people living with HIV have a higher risk of heart disease.
-
Clonal blood mutations and chromosome changes linked to heart disease in people with HIV
Researchers will look for whether age-related blood mutations and large chromosome changes raise heart disease risk in people living with HIV.
-
How Lp(a) levels affect heart and artery disease risk in people with HIV
This project looks at whether higher levels of a blood lipid called Lp(a) raise the chance of heart and artery disease for people living with HIV.
-
Investigating the link between aging, HIV, and heart disease
This study is looking at how getting older and living with HIV can raise the chances of heart problems in older adults, and it aims to find ways to help reduce that risk by understanding the biological changes involved.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.