Cardiac health and protein biomarkers in kids with perinatal HIV exposure or infection
Official title: Cardiac function and proteomic biomarkers in individuals with perinatal HIV infection or exposure
Funded at Duke University · NIH-11408537 · Data updated 2026-11-12
A study to understand how perinatal HIV infection or exposure affects heart function and biomarkers in children and teens, to help prevent future heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 5, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $677,875 |
| NIH project number | 5R01HL176320-02 |
| Project ID | NIH-11408537 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and adolescents with perinatal HIV infection, perinatal HIV exposure without infection, and HIV-unexposed uninfected peers.
✕Less likely to help
Youth without perinatal HIV exposure or infection who do not participate in imaging or biomarker studies would not directly benefit.
What this research studies
This project will compare heart structure and function, autonomic nervous system performance, physical abilities, and molecular markers between youths with perinatal HIV infection, those exposed but uninfected, and those without exposure. It uses advanced heart imaging, physical tests, and proteomic profiling to find clues of early, subclinical heart changes. The goal is to identify who is at risk and what early interventions might help keep hearts healthier as they grow.
Why it matters
Potential benefit: If successful, findings could guide earlier screening and personalized care to prevent cardiac problems in pnHIV-affected youth.
How similar studies have gone: Previous research suggests potential cardiac differences in pnHIV, but comprehensive imaging and proteomic profiling in this population is novel and exploratory.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Bloomfield, Gerald Samuel — Duke University
- Study coordinator: Bloomfield, Gerald Samuel
Related research
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Cardiac health and protein markers in kids with perinatal HIV exposure or infection
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.