Understanding how sex affects early HIV-1 subtype C infection and treatment response
Official title: Deciphering the impact of sex in early subtype C HIV infection and during HART
Funded at Emory University · NIH-11548392 · Data updated 2026-11-12
Researchers are studying how men and women may experience subtype C HIV differently early after infection and during treatment, which could lead to more personalized care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | July 11, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $63,564 |
| NIH project number | 3R01AI172740-05S1 |
| Project ID | NIH-11548392 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with acute/subtype C HIV-1 infection, especially adults in or from regions with similar epidemiology, who are or will be treated with ART.
✕Less likely to help
People without HIV or with non-subtype C infections may not directly benefit from these findings.
What this research studies
This project looks at subtype C HIV-1 in acutely infected individuals from Zambia to compare viral, transcriptional, and immune features between sexes. By using a unique cohort with samples collected before widespread antiretroviral therapy, the study aims to uncover sex-specific differences that could influence treatment outcomes. The results could inform approaches to protect health and optimize therapies for both men and women in the U.S. and globally. Collaboration with Emory University enables rigorous analysis while leveraging international samples.
Why it matters
Potential benefit: Findings could guide more effective, sex-informed prevention and treatment strategies for HIV-1 subtype C.
How similar studies have gone: Previous work has shown sex-based differences in HIV pathogenesis and treatment response, supporting potential for meaningful insights in this area.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Hunter, Eric — Emory University
- Study coordinator: Hunter, Eric
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.