CMV, immune activation, and early-life exposure shaping neurodevelopment in children born to mothers with HIV
Official title: The effect of cytomegalovirus, inflammation, and immune activation on neurodevelopment in children exposed to maternal HIV infection
Funded at University of Washington · NIH-11408475 · Data updated 2026-11-12
This project studies how exposure to maternal HIV and early CMV infection might affect a child’s brain development and behavior as they grow.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 4, 2025 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $243,876 |
| NIH project number | 5P01HD107669-03 |
| Project ID | NIH-11408475 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 years who were exposed to maternal HIV infection at birth.
✕Less likely to help
Non-exposed children or those without CMV exposure may not directly benefit from this study.
What this research studies
If funded, researchers will follow children born to mothers with HIV to see how CMV infection and immune system activation in early life relate to later cognitive and motor development. The study uses blood tests and developmental assessments over time to understand biological and social factors that influence outcomes. By tracking inflammation, immune markers, and neurodevelopmental measures, they aim to connect early-life infections with later child functioning in a real-world setting.
Why it matters
Potential benefit: If successful, findings could inform strategies to reduce infection-related inflammation and improve developmental outcomes for HEU children.
How similar studies have gone: Previous work shows associations between early CMV/inflammation and developmental outcomes, but causal pathways remain to be clarified.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Slyker, Jennifer Ann — University of Washington
- Study coordinator: Slyker, Jennifer Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.