Understanding how genetic changes in blood cells relate to heart disease in people with HIV

Who could benefit from this research

What this research studies

This project will enroll people living with HIV as they age to examine whether specific blood cell mutations and chromosomal changes are linked to higher rates of cardiovascular disease. Researchers will analyze blood samples to identify clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs), and relate these findings to cardiovascular outcomes. By investigating immune pathways such as NLRP3/IL-1β/IL-6, the study aims to uncover biological connections between HIV, aging, and heart health. The results could point to new biomarkers or pathways for preventing heart disease in PLWH.

Why it matters

Where this research is happening

• University of California Los Angeles
  Los Angeles, United States Active

Researchers

• Principal investigator: Hsue, Priscilla Y. — University of California Los Angeles
• Study coordinator: Hsue, Priscilla Y.

Related research

Other NIH-funded projects on the same topics.

• Lp(a) and HIV: Understanding Heart Disease Risk in HIV Patients

  This program looks at how Lipoprotein(a) contributes to higher heart disease risk in people with HIV and what Lp(a) levels mean for future treatments.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11402774

• Understanding how age-related blood changes affect heart disease risk in people with HIV

  This study looks at whether certain blood-level genetic changes and chromosome alterations in people living with HIV relate to higher risk of heart disease.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11379983

• Blood cell mutations, chromosome changes, and heart disease in people living with HIV

  This project looks at whether age-related blood cell mutations and large chromosome changes help explain why people living with HIV have a higher risk of heart disease.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11373117

• Clonal blood mutations and chromosome changes linked to heart disease in people with HIV

  Researchers will look for whether age-related blood mutations and large chromosome changes raise heart disease risk in people living with HIV.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11181024

• How Lp(a) levels affect heart and artery disease risk in people with HIV

  This project looks at whether higher levels of a blood lipid called Lp(a) raise the chance of heart and artery disease for people living with HIV.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11166455

• Investigating the link between aging, HIV, and heart disease

  This study is looking at how getting older and living with HIV can raise the chances of heart problems in older adults, and it aims to find ways to help reduce that risk by understanding the biological changes involved.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11145531

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.