Understanding how IL-33 helps protect heart transplants
Immunoregulatory Mechanisms of IL-33 in Heart Transplantation
This study is looking at how a substance called IL-33 can help reduce inflammation and support healing in kids who have received heart transplants, by understanding how it affects the immune system's response to the new heart.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10880447 on NIH RePORTER |
What this research studies
This research investigates the role of Interleukin-33 (IL-33) in heart transplantation, focusing on how it can limit inflammation and promote tissue repair after a transplant. By studying samples from pediatric heart transplant recipients and using mouse models, the research aims to understand how IL-33 can mitigate damage caused by the immune response to transplanted organs. The approach involves analyzing the immune cells involved in graft rejection and how IL-33 influences their behavior to improve transplant outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients undergoing heart transplantation or those who have received a heart transplant.
Not a fit: Patients who are not undergoing heart transplantation or who have other unrelated medical conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing rejection and enhancing the longevity of heart transplants.
How similar studies have performed: Previous research has shown promising results in using similar immunoregulatory approaches to improve transplant outcomes, indicating potential for success in this area.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Turnquist, Heth R — University of Pittsburgh at Pittsburgh
- Study coordinator: Turnquist, Heth R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.