Metabolic deterioration after heart transplant determines outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, longitudinal cohort of adult heart transplant recipients using advanced, multi-modal phenotyping to link metabolic changes with cardiac and systemic organ function. Participants undergo serial cardiac imaging (echocardiography, cardiac MRI, and MR spectroscopy), coronary angiography, protocol endomyocardial biopsies, and detailed metabolic testing including oral glucose tolerance tests, insulin-resistance measures, diabetes endotyping, and muscle biopsies. The study tracks changes over time to determine how metabolic deterioration relates to coronary allograft vasculopathy, rejection, renal and hepatic dysfunction, and clinical outcomes. Findings aim to define optimal metabolic surveillance and timing for interventions after transplant.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age: ≥ 18 years
* Planned or already conducted heart transplantation
* Informed consent

Exclusion Criteria:

* Absence of informed consent

Where it's running

• University-Hospital Düsseldorf Division of Cardiology, Pneumology and Angiology
  Düsseldorf, North Rhine-Westphalia, Germany Recruiting

Study contacts

• Study coordinator: Amin Polzin, Prof.
• Email: amin.polzin@med.uni-duesseldorf.de
• Phone: 0211 81 18801

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Nationwide Swedish program testing donor-derived cell-free DNA to monitor rejection after heart transplant

  This project tests whether a blood test measuring donor-derived cell-free DNA can help monitor rejection in adults who have had a heart transplant.

  Recruiting Karolinska Institutet · Stockholm · NCT07531784

• Mapping fat-cell sizes around the coronary arteries to trace inflammation

  This project will test whether differences in fat-cell size next to the coronary arteries can show how inflammation spreads in people having a heart transplant for advanced heart failure.

  Recruiting Institute for Clinical and Experimental Medicine · Prague · NCT07360925

• Multimodal analysis of heart biopsy samples

  This project will take one extra small heart biopsy during a clinically needed procedure to test whether detailed molecular and immune analyses can find disease-specific signatures in adults with cardiomyopathies, myocarditis, cardiac amyloidosis, or after heart transplant.

  Recruiting University Hospital, Essen · Essen, North Rhine-Westphalia · NCT07359690

• Long-term health of children born to mothers who had a solid organ transplant

  This project will look for long-term heart, kidney, and immune system problems in people aged 16 and older who were born to mothers who had a kidney, liver, pancreas, heart, or lung transplant.

  Recruiting University Medical Center Groningen · Groningen, Provincie Groningen · NCT07291258

• Cardiac rehabilitation cohort at Medicine Campus Davos to explore recovery

  This project will follow adults coming to Hochgebirgsklinik Davos for cardiac rehabilitation to see how their heart health and recovery progress over time.

  Recruiting Hochgebirgsklinik Davos · Davos, Kanton Graubünden · NCT07096973

• Predicting heart transplant outcomes using donor heart biopsies

  This study is testing if looking at tissue samples from donor hearts can help predict how well the transplanted hearts will work and if they'll be rejected by the recipient's body.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT06982404

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.