Condition

Hypertrophic Cardiomyopathy (HCM) clinical trials and research

• 14Clinical trials
• 6Countries

Newest Hypertrophic Cardiomyopathy (HCM) clinical trials

All recruiting trials (14)

• Transitioning from mavacamten to aficamten in obstructive HCM

  This study tests whether switching from mavacamten to aficamten is feasible and safe for people with obstructive hypertrophic cardiomyopathy who are already on mavacamten.

  Recruiting Phase 4 Oregon Health and Science University · Kansas City, Missouri and 1 other locations · NCT07600177

• 68Ga-NI-FAPI-04 PET/CT imaging to detect fibroblast activation in cancer, fibrotic, and heart diseases

  This test will see if an injected PET tracer called 68Ga-NI-FAPI-04 can better show fibroblast activation in people with tumors, pulmonary fibrosis, certain autoimmune vascular diseases, hypertrophic cardiomyopathy, or other cardiovascular conditions.

  Recruiting Phase 1/2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07464132

• Understanding why AF happens and is harder to treat in hypertrophic cardiomyopathy

  We’re testing how heart electrical signals and advanced imaging relate to atrial fibrillation in people with hypertrophic cardiomyopathy to see if treatments can be improved.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London · NCT07454135

• UK multicentre hypertrophic cardiomyopathy registry

  This project collects health information from adults with hypertrophic cardiomyopathy across UK NHS hospitals to see which treatments and tests work best for different patients.

  Recruiting University of Manchester · Manchester · NCT07381894

• Multimodal analysis of heart biopsy samples

  This project will take one extra small heart biopsy during a clinically needed procedure to test whether detailed molecular and immune analyses can find disease-specific signatures in adults with cardiomyopathies, myocarditis, cardiac amyloidosis, or after heart transplant.

  Recruiting University Hospital, Essen · Essen, North Rhine-Westphalia · NCT07359690

• T1 mapping to characterize heart tissue in common heart diseases

  This project tests whether T1 mapping MRI scans, including dye-free native T1, can define normal and disease-specific heart tissue values for adults with various heart conditions.

  Recruiting Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing, Beijing Municipality · NCT07354646

• Natural history of RASopathy-associated cardiomyopathy in infants and children

  This project collects clinical and genetic records from infants and children with genetically confirmed RASopathy-associated hypertrophic cardiomyopathy to create a comparison dataset for future treatments.

  Recruiting Deutsches Herzzentrum Muenchen · München · NCT07344480

• AI-powered ECG diagnosis and prognosis for hypertrophic cardiomyopathy

  This project will test whether artificial intelligence reading standard 12-lead ECGs can identify different types of hypertrophic cardiomyopathy and tell them apart from look‑alike heart conditions in adults.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07263204

• Rivaroxaban for preventing problems in adults with hypertrophic cardiomyopathy and abnormal left atrial strain

  This study tests whether rivaroxaban can prevent complications in adults with hypertrophic cardiomyopathy who have abnormal left atrial strain and are in sinus rhythm.

  Recruiting at 2 sites Phase 3 Rennes University Hospital · Angers and 16 other locations · NCT07202897

• HCMR Re-Imaging for Hypertrophic Cardiomyopathy Follow-up

  We will do follow-up heart MRI scans to see if gadolinium scarring (LGE) predicts future dangerous heart rhythms or heart failure in adults who were in the original HCMR cohort and have hypertrophic cardiomyopathy.

  Recruiting at 3 sites University of Virginia · Boston, Massachusetts and 7 other locations · NCT07054073

• Using AI to enhance cardiology patient care

  This study is testing if using AI tools can help cardiologists make better decisions when treating patients with heart conditions compared to traditional methods.

  Recruiting Stanford University · Palo Alto, California · NCT06935253

• Identifying patients with cardiomyopathy for potential heart transplantation

  This study is trying to find new ways to identify and understand cardiomyopathy in patients to better predict if they might need a heart transplant in the future.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Emilia-Romagna/Bologna and 2 other locations · NCT06813443

• Real-world look at hypertrophic cardiomyopathy in adults in China

  This real-world study tests how adults with hypertrophic cardiomyopathy in China are diagnosed and treated over time, based on standard care.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 1 other locations · NCT06775665

• Registry for patients with non-ischemic cardiomyopathies

  This study is collecting information from people with non-ischemic cardiomyopathies to see how to better diagnose and manage their condition and predict potential heart rhythm problems.

  Recruiting Scientific Institute San Raffaele · Milan, Milano · NCT06607471

Related topics

Quick answers

How many Hypertrophic Cardiomyopathy (HCM) clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in China (4 trials), United Kingdom (3 trials), United States (3 trials), Germany (2 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1, Phase 4: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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