Using advanced methods to manage heart transplant patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to utilize a multiparametric approach that integrates biomolecular, histological, imaging, and clinical data to identify heart transplant recipients at higher risk for rejection, infections, and chronic graft dysfunction. Patients will undergo standard clinical practices, including myocardial biopsies, while additional non-invasive investigations and analyses will be performed to correlate findings with histopathological results. The study will also explore the use of machine learning techniques to develop predictive algorithms for rejection risk based on these comprehensive data sets.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Have received an orthotopic heart transplant
* Clinical indication for performing a myocardial biopsy (either as part of standard monitoring or for suspected rejection)
* Obtaining informed consent

Exclusion Criteria:

* Severe complications in the post-operative phase that may limit the patient's short-term survival.

Where it's running

• Luciano
  Bologna, Italy Recruiting

Study contacts

• Principal investigator: Luciano G Potena, MD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
• Study coordinator: Luciano Potena, MD
• Email: scompenso.trapiantocuore@aosp.bo.it
• Phone: 0512143725

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Nationwide Swedish program testing donor-derived cell-free DNA to monitor rejection after heart transplant

  This project tests whether a blood test measuring donor-derived cell-free DNA can help monitor rejection in adults who have had a heart transplant.

  Recruiting Karolinska Institutet · Stockholm · NCT07531784

• Metabolic deterioration after heart transplant determines outcomes

  We'll test whether worsening cardiac and systemic metabolism after a heart transplant predicts heart function and long-term survival in adult transplant recipients.

  Recruiting Heinrich-Heine University, Duesseldorf · Düsseldorf, North Rhine-Westphalia · NCT07372820

• Mapping fat-cell sizes around the coronary arteries to trace inflammation

  This project will test whether differences in fat-cell size next to the coronary arteries can show how inflammation spreads in people having a heart transplant for advanced heart failure.

  Recruiting Institute for Clinical and Experimental Medicine · Prague · NCT07360925

• Multimodal analysis of heart biopsy samples

  This project will take one extra small heart biopsy during a clinically needed procedure to test whether detailed molecular and immune analyses can find disease-specific signatures in adults with cardiomyopathies, myocarditis, cardiac amyloidosis, or after heart transplant.

  Recruiting University Hospital, Essen · Essen, North Rhine-Westphalia · NCT07359690

• Long-term health of children born to mothers who had a solid organ transplant

  This project will look for long-term heart, kidney, and immune system problems in people aged 16 and older who were born to mothers who had a kidney, liver, pancreas, heart, or lung transplant.

  Recruiting University Medical Center Groningen · Groningen, Provincie Groningen · NCT07291258

• Cardiac rehabilitation cohort at Medicine Campus Davos to explore recovery

  This project will follow adults coming to Hochgebirgsklinik Davos for cardiac rehabilitation to see how their heart health and recovery progress over time.

  Recruiting Hochgebirgsklinik Davos · Davos, Kanton Graubünden · NCT07096973

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.