Identifying risks of heart transplant rejection before surgery
Official title: Pre-Transplant Multiomic Profiling to Quantify The Risk of Rejection Following Heart Transplantation
Funded at Ut Southwestern Medical Center · NIH-10985915 · Data updated 2026-11-12
This study is looking to help heart transplant patients by finding out who is less likely to reject their new heart before the surgery, so they can take fewer medications that might cause side effects and enjoy better long-term health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $185,579 |
| NIH project number | 1K23HL171828-01A1 |
| Project ID | NIH-10985915 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are preparing for a heart transplant and may benefit from a personalized assessment of their rejection risk.
✕Less likely to help
Patients who are not candidates for heart transplantation or those who have already undergone the procedure may not benefit from this research.
What this research studies
This research aims to improve outcomes for heart transplant recipients by identifying patients at low risk for rejection before the transplant occurs. It utilizes advanced multi-omic technologies to analyze existing biospecimens and discover new biomarkers that can predict rejection risk. By understanding these risks, the study seeks to safely reduce the need for immunosuppressive medications, which can have serious side effects. This approach could lead to better management of heart transplant patients and enhance their long-term health.
Why it matters
Potential benefit: If successful, this research could lead to safer heart transplant procedures with fewer complications and improved survival rates for patients.
How similar studies have gone: Other research has shown promise in using multi-omic profiling to assess transplant risks, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Truby, Lauren Kathryn — Ut Southwestern Medical Center
- Study coordinator: Truby, Lauren Kathryn
Related research
Other NIH-funded projects on the same topics.
-
Predicting Heart Transplant Rejection Risk Before Surgery
This research aims to find ways to predict which heart transplant patients might reject their new heart, helping doctors tailor their medication plans.
-
Immunological mechanisms behind treatment-resistant kidney transplant rejection
This grant explores why certain kidney transplant rejections don’t respond to standard treatments and what immune cells in the graft are driving that resistance.
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Understanding how BK virus links infection to kidney transplant rejection
This project looks at how BK polyomavirus reactivation affects kidney transplant patients and aims to use pre-transplant T cell information to tailor immunosuppression and monitoring.
-
Biomarkers to tailor liver transplant immunosuppression
A multi-center study using blood biomarkers to guide how immunosuppressive drugs are given to liver transplant patients.
-
Using blood biomarkers to guide immunosuppression after liver transplant
This project uses regular blood biomarker checks to help doctors personalize immunosuppression for people who have had a liver transplant to reduce rejection and protect the kidneys.
-
Targeting YAP and TAZ with statins to prevent transplant rejection from donor antibodies
A study to see if statins can block specific gene regulators (YAP and TAZ) to protect transplanted organs from rejection caused by donor antibodies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.