Identifying risks of heart transplant rejection before surgery
Pre-Transplant Multiomic Profiling to Quantify The Risk of Rejection Following Heart Transplantation
This study is looking to help heart transplant patients by finding out who is less likely to reject their new heart before the surgery, so they can take fewer medications that might cause side effects and enjoy better long-term health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10985915 on NIH RePORTER |
What this research studies
This research aims to improve outcomes for heart transplant recipients by identifying patients at low risk for rejection before the transplant occurs. It utilizes advanced multi-omic technologies to analyze existing biospecimens and discover new biomarkers that can predict rejection risk. By understanding these risks, the study seeks to safely reduce the need for immunosuppressive medications, which can have serious side effects. This approach could lead to better management of heart transplant patients and enhance their long-term health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are preparing for a heart transplant and may benefit from a personalized assessment of their rejection risk.
Not a fit: Patients who are not candidates for heart transplantation or those who have already undergone the procedure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer heart transplant procedures with fewer complications and improved survival rates for patients.
How similar studies have performed: Other research has shown promise in using multi-omic profiling to assess transplant risks, suggesting that this approach could yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Truby, Lauren Kathryn — Ut Southwestern Medical Center
- Study coordinator: Truby, Lauren Kathryn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.