Predicting Heart Transplant Rejection Risk Before Surgery
Official title: Pre-Transplant Multiomic Profiling to Quantify The Risk of Rejection Following Heart Transplantation
Funded at Ut Southwestern Medical Center · NIH-11180489 · Data updated 2026-11-12
This research aims to find ways to predict which heart transplant patients might reject their new heart, helping doctors tailor their medication plans.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $183,579 |
| NIH project number | 5K23HL171828-02 |
| Project ID | NIH-11180489 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research uses existing information and samples from heart transplant recipients to understand factors related to rejection.
✕Less likely to help
Patients who have not undergone a heart transplant or are not at risk for rejection would not directly benefit from this specific research.
What this research studies
Many people who receive a heart transplant face the risk of their body rejecting the new heart, which can lead to serious health problems. Currently, it's hard to know who is at highest risk before the transplant, making it difficult to adjust medications like immunosuppressants. While these medications prevent rejection, they can also cause side effects like infections or kidney issues. This project uses advanced technologies to look at many biological markers in blood samples taken before transplant, hoping to identify a patient's individual risk for rejection and potentially allow doctors to reduce strong medications for those at lower risk.
Why it matters
Potential benefit: If successful, this work could help doctors personalize medication plans for heart transplant recipients, potentially reducing side effects while still preventing rejection.
How similar studies have gone: While non-invasive tests exist to diagnose rejection after transplant, there is currently no established test to quantify rejection risk before transplant, making this approach novel.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Truby, Lauren Kathryn — Ut Southwestern Medical Center
- Study coordinator: Truby, Lauren Kathryn
Related research
Other NIH-funded projects on the same topics.
-
Identifying risks of heart transplant rejection before surgery
This study is looking to help heart transplant patients by finding out who is less likely to reject their new heart before the surgery, so they can take fewer medications that might cause side effects and enjoy better long-term health.
-
Immunological mechanisms behind treatment-resistant kidney transplant rejection
This grant explores why certain kidney transplant rejections don’t respond to standard treatments and what immune cells in the graft are driving that resistance.
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Understanding how BK virus links infection to kidney transplant rejection
This project looks at how BK polyomavirus reactivation affects kidney transplant patients and aims to use pre-transplant T cell information to tailor immunosuppression and monitoring.
-
Biomarkers to tailor liver transplant immunosuppression
A multi-center study using blood biomarkers to guide how immunosuppressive drugs are given to liver transplant patients.
-
Using blood biomarkers to guide immunosuppression after liver transplant
This project uses regular blood biomarker checks to help doctors personalize immunosuppression for people who have had a liver transplant to reduce rejection and protect the kidneys.
-
Targeting YAP and TAZ with statins to prevent transplant rejection from donor antibodies
A study to see if statins can block specific gene regulators (YAP and TAZ) to protect transplanted organs from rejection caused by donor antibodies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.