Predicting Heart Transplant Rejection Risk Before Surgery
Pre-Transplant Multiomic Profiling to Quantify The Risk of Rejection Following Heart Transplantation
['FUNDING_OTHER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11180489
This research aims to find ways to predict which heart transplant patients might reject their new heart, helping doctors tailor their medication plans.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11180489 on ClinicalTrials.gov |
What this research studies
Many people who receive a heart transplant face the risk of their body rejecting the new heart, which can lead to serious health problems. Currently, it's hard to know who is at highest risk before the transplant, making it difficult to adjust medications like immunosuppressants. While these medications prevent rejection, they can also cause side effects like infections or kidney issues. This project uses advanced technologies to look at many biological markers in blood samples taken before transplant, hoping to identify a patient's individual risk for rejection and potentially allow doctors to reduce strong medications for those at lower risk.
Who could benefit from this research
Good fit: This research uses existing information and samples from heart transplant recipients to understand factors related to rejection.
Not a fit: Patients who have not undergone a heart transplant or are not at risk for rejection would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help doctors personalize medication plans for heart transplant recipients, potentially reducing side effects while still preventing rejection.
How similar studies have performed: While non-invasive tests exist to diagnose rejection after transplant, there is currently no established test to quantify rejection risk before transplant, making this approach novel.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TRUBY, LAUREN KATHRYN — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: TRUBY, LAUREN KATHRYN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers