Mapping fat-cell sizes around the coronary arteries to trace inflammation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will collect explanted hearts during heart transplantation at IKEM from patients with ischemic or dilated cardiomyopathy. Pericoronary adipose tissue samples close to and farther from the arterial lumen will be analyzed for adipocyte size, immunometabolic markers, and macrophage changes to create spatial gradients. Clinical data including age, BMI, comorbidities, medications and prior LVAD use will be recorded to relate tissue findings to patient context and altered coronary flow. Results will compare patients with advanced atherosclerosis to those with less atherosclerotic disease to determine patterns of local inflammation propagation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 30-90 years
* Diagnosis of dilatational or ischemic cardiomyopathy
* Patients undergoing heart transplantation in IKEM

Exclusion Criteria:

* Known combined diagnosis of dilatational and ischemic cardiomyopathy
* Arrhythmogenic cardiomyopathy
* Congenital heart defects
* Non-eligibility due to the absence of informed consent

Where it's running

• Centre of Experimental Medicine, Institute for Clinical and Experimental Medicine,
  Prague, Czechia Recruiting

Study contacts

• Study coordinator: Ivana K Lesna, MD, PhD., assoc. prof.
• Email: ivana.kralova.lesna@ikem.cz
• Phone: 00420236055445

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.