Non-invasive brain stimulation for neurodegenerative diseases
Non-invasive Neurostimulation as a Tool for Diagnostics and Management for Neurodegenerative Diseases
This study is testing if a new type of brain stimulation can help relieve symptoms in people with neurodegenerative diseases like Alzheimer's and dementia.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Kuopio University Hospital Academic / other |
| Locations | 1 site (Kuopio) |
| Trial ID | NCT05326750 on ClinicalTrials.gov |
What this trial studies
This trial investigates the effects of repeated transcranial alternating current stimulation (tACS) on patients with neurodegenerative diseases such as Alzheimer's disease, Frontotemporal dementia, and Dementia with Lewy Bodies. It is a double-blinded, sham-controlled, randomized trial where participants will receive stimulation four times daily on the posterior parietal cortex. The goal is to determine if this non-invasive approach can alleviate symptoms associated with these conditions.
Who should consider this trial
Good fit: Ideal candidates include individuals with mild cognitive impairment due to Alzheimer's disease, Dementia with Lewy Bodies, Frontotemporal dementia, or idiopathic normal pressure hydrocephalus.
Not a fit: Patients with a history of seizures, pregnancy, metal implants in the head, electronic implants, or those under 18 years old may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a new non-invasive treatment option to improve symptoms in patients with neurodegenerative diseases.
How similar studies have performed: While the use of tACS is gaining interest, this specific application in neurodegenerative diseases is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Mild Cognitive Impairment due to Alzheimer's disease * Dementia with Lewy Bodies * Frontotemporal dementia * Idiopathic normal pressure hydrocephalus (iNPH) Exclusion Criteria: * History of seizures * Pregnancy * Metal implants in the head (except dental fillings) * Electronic implants (i.e. pace-maker, implanted medical pump) * Age \<18 years
Where this trial is running
Kuopio
- Kuopio University Hospital — Kuopio, Finland (Recruiting)
Study contacts
- Principal investigator: Eino Solje, MD, PhD — Kuopio University Hospital
- Study coordinator: Eino Solje, MD, PhD
- Email: eino.solje@uef.fi
- Phone: +358 17 713 311
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.