Non-invasive brain stimulation for neurodegenerative diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the effects of repeated transcranial alternating current stimulation (tACS) on patients with neurodegenerative diseases such as Alzheimer's disease, Frontotemporal dementia, and Dementia with Lewy Bodies. It is a double-blinded, sham-controlled, randomized trial where participants will receive stimulation four times daily on the posterior parietal cortex. The goal is to determine if this non-invasive approach can alleviate symptoms associated with these conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Mild Cognitive Impairment due to Alzheimer's disease
* Dementia with Lewy Bodies
* Frontotemporal dementia
* Idiopathic normal pressure hydrocephalus (iNPH)

Exclusion Criteria:

* History of seizures
* Pregnancy
* Metal implants in the head (except dental fillings)
* Electronic implants (i.e. pace-maker, implanted medical pump)
* Age \<18 years

Where it's running

• Kuopio University Hospital
  Kuopio, Finland Recruiting

Study contacts

• Principal investigator: Eino Solje, MD, PhD — Kuopio University Hospital
• Study coordinator: Eino Solje, MD, PhD
• Email: eino.solje@uef.fi
• Phone: +358 17 713 311

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Predicting disease progression in dementia using biomarkers and modeling

  This study is trying to create a tool that helps predict how dementia will progress in people with mild cognitive impairment and different types of dementia, like Alzheimer's and Lewy Body Disease, by looking at brain scans, body fluids, and mental tests.

  Recruiting University Health Network, Toronto · North York, Ontario and 3 other locations · NCT06529744

• Collection of cerebrospinal fluid for cognitive disorder research

  This study is collecting spinal fluid from people with cognitive disorders like Alzheimer's and dementia to help improve how these diseases are diagnosed.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT04844060

• Hyperspectral retinal imaging to detect Alzheimer’s and other neurodegenerative changes

  This project will test whether a special retinal camera that scans many wavelengths of light can detect signs of Alzheimer’s and other neurodegenerative diseases in people with dementia or at risk.

  Recruiting Center for Eye Research Australia · Melbourne, Victoria · NCT07545473

• ARO-MAPT-SC in healthy adults and people with early Alzheimer's disease

  This trial will test whether ARO-MAPT-SC is safe, tolerable, and produces the expected drug levels and biomarker effects in healthy adults and people with early Alzheimer's disease.

  Recruiting at 4 sites Phase 1/2 Arrowhead Pharmaceuticals · East York, Ontario and 3 other locations · NCT07221344

• Comparing protein patterns in skin biopsies of neurodegenerative diseases

  This study is trying to see if the patterns of certain proteins in skin samples can help doctors better understand and diagnose different neurodegenerative diseases like Alzheimer's, Parkinson's, and frontotemporal dementia.

  Recruiting Universidad Autonoma de San Luis Potosí · San Luis Potosí City · NCT06528964

• Advancing genomic medicine using electronic health records

  This study is trying to see if using electronic health records and helpful reminders can get more patients tested for genetic conditions in a way that doctors can easily use.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT06377033

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.