Condition

Huntington Disease clinical trials and research

• 31Clinical trials
• 11NIH research projects
• 32Countries

Newest Huntington Disease clinical trials

All recruiting trials (31)

• Pridopidine for Huntington's Disease: a 1-year, randomized, placebo-controlled study

  This trial tests whether pridopidine can slow the progression of Huntington's disease in adults compared with placebo over one year.

  Recruiting at 17 sites Phase 3 Prilenia · Birmingham, Alabama and 65 other locations · NCT07609108

• Low-intensity focused ultrasound targeting the globus pallidus to improve movement in Huntington's disease

  This trial tests whether different pulse frequencies of low-intensity focused ultrasound (LIFU) aimed at a deep brain target can safely reduce chorea and other motor symptoms in adults with Huntington's disease.

  Recruiting First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT07513844

• Safety and tolerability of human neural stem cell implants for Huntington's disease

  This research will test whether an implant of hNSC-01 human neural stem cells is safe and tolerable for adults with Huntington's disease.

  Recruiting Phase 1/2 University of California, Irvine · Irvine, California · NCT07451613

• SKY-0515 for adults with Huntington's disease

  This trial will test whether the oral drug SKY-0515 can lower harmful huntingtin protein and improve symptoms in adults aged 25 and older with genetically confirmed Huntington's disease.

  Recruiting at 19 sites Phase 2/3 Skyhawk Therapeutics, Inc. · Englewood, Colorado and 30 other locations · NCT07378644

• Votoplam for adults with early symptomatic Huntington's disease

  This trial will test whether votoplam (HTT227) is safe and can slow disease progression in adults with early symptomatic Huntington's disease.

  Recruiting at 117 sites Phase 3 Novartis · Birmingham, Alabama and 116 other locations · NCT07326709

• Comparing three social cognition tests in adults with early Huntington disease

  This project will test whether the DMASC-MC and two established social cognition tests can detect social thinking problems in adults with early Huntington disease.

  Recruiting Region Skane · Lund · NCT07253038

• Wearable monitoring of walking and arm movement in adults with neuromuscular or metabolic movement disorders

  This project uses a wrist/ankle wearable to continuously monitor walking and upper-limb movement in ambulant adults with neuromuscular diseases or obesity to see if digital measures like stride speed track real-life motor function.

  Recruiting Centre Hospitalier Universitaire de Liege · Liège · NCT07136844

• Wearable sensors to track walking and involuntary movements in Huntington's disease

  This study will try whether wrist and body-worn sensors plus virtual visits can track gait changes and chorea in adults with Huntington's disease and in healthy adults.

  Recruiting University of Rochester · Rochester, New York · NCT07010705

• Biobank for monitoring and understanding Huntington's disease

  This study is trying to find new ways to track Huntington's disease by using home monitoring and tests to see how it changes over time for people living with the condition.

  Recruiting Stanford University · Palo Alto, California · NCT06941662

• Investigating Nicotinamide Riboside for Huntington's Disease

  This study is testing if a vitamin B3 supplement called nicotinamide riboside can help slow down Huntington's disease in adults compared to a placebo.

  Recruiting Phase 2 Oslo University Hospital · Oslo · NCT06853743

• Home-based tDCS to help thinking and behavior in Huntington's disease

  This project will test whether daily at-home transcranial direct current stimulation (tDCS) can help thinking and behavioral symptoms in adults with early-to-moderate Huntington's disease.

  Recruiting The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT06843252

• Gene therapy for Huntington's Disease using SPK-10001

  This study is testing a new gene therapy called SPK-10001 to see if it can safely help people with Huntington's Disease feel better.

  Recruiting at 5 sites Phase 1/2 Hoffmann-La Roche · Boston, Massachusetts and 4 other locations · NCT06826612

• Hinting Task to measure social thinking in Huntington's disease

  This research will test whether the Hinting Task can reliably measure Theory of Mind (social thinking) in Dutch-speaking adults with Huntington's disease.

  Recruiting University Medical Center Groningen · Groningen, Provincie Groningen · NCT06774443

• New PET tracer ([11C]CHDI-00491009) to image mutant huntingtin in Huntington disease

  This project will test a new PET tracer ([11C]CHDI-00491009) to see if it binds mutant huntingtin aggregates in adults with Huntington disease and in healthy volunteers.

  Recruiting Early Phase 1 CHDI Foundation, Inc. · Leuven · NCT06634628

• Investigating early biomarkers in gene carriers of Huntington's disease

  This study is testing if brain scans and virtual reality can help find early signs of Huntington's disease in people who carry the gene but don't have symptoms yet.

  Recruiting University Hospital, Grenoble · Grenoble · NCT06626308

• Using SAGE and a Coding test to check thinking skills in Huntington's disease

  We will test whether two quick thinking tests—the Self‑Administered Gerocognitive Examination (SAGE) and a Coding test—work well for adults with genetic Huntington's disease.

  Recruiting Ohio State University · Columbus, Ohio · NCT06546488

• Collecting health information from individuals with Huntington Disease

  This study is collecting health information from people with Huntington Disease to better understand how the condition affects them over time using an online platform.

  Recruiting Huntington Study Group · Rochester, New York · NCT06475898

• Gut bacteria in Huntington disease

  This project will try to see if adults with Huntington's disease who worsen quickly have different gut bacteria than those who progress more slowly.

  Recruiting University of Central Florida · Orlando, Florida · NCT06448546

• Evaluating music therapy for irritability and impulsivity in Huntington's disease

  This study is testing if music therapy can help reduce irritability and impulsivity in people with early-stage Huntington's disease.

  Recruiting Poitiers University Hospital · Poitiers · NCT06414967

• Biobank for studying ALS and Alzheimer's diseases

  This study is collecting blood, skin samples, and health information from people to see how genetics might help us understand and find treatments for ALS and Alzheimer's disease.

  Recruiting New York Stem Cell Foundation Research Institute · New York, New York · NCT06203106

• Non-invasive prenatal diagnosis for single gene disorders

  This study is testing a new way to safely diagnose single-gene disorders in unborn babies using a simple blood test from the mother, starting as early as 9 weeks into the pregnancy.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06147414

• Using blood samples to find biomarkers for Huntington Disease

  This study is trying to find signs in blood samples that could help track Huntington Disease by looking at tiny particles released from brain cells in people with the disease compared to healthy individuals.

  Recruiting University of Central Florida · Orlando, Florida · NCT06082713

• Testing a new drug VO659 for genetic neurodegenerative diseases

  This study is testing a new drug called VO659 to see if it is safe and can help people with spinocerebellar ataxia types 1 and 3 or Huntington's disease.

  Recruiting at 12 sites Phase 1/2 Vico Therapeutics B. V. · Copenhagen and 13 other locations · NCT05822908

• Using new imaging and cognitive biomarkers to predict progression in Huntington's disease

  This study is testing new imaging and brain function markers to see if they can help predict how Huntington's disease will progress in people who have it and those who might get it in the future.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil, Île-de-France Region · NCT05808153

• Testing N-Acetyl Cysteine for people at risk of Huntington's Disease

  This study is testing if taking N-Acetyl Cysteine can help people who are at risk for Huntington's Disease delay the start of symptoms.

  Recruiting Phase 2 Western Sydney Local Health District · Westmead, New South Wales and 4 other locations · NCT05509153

• Comparing two PET imaging techniques in Huntington Disease

  This study is testing two different PET imaging techniques to see which one better shows changes in the brain of people with Huntington Disease and how those changes relate to movement problems.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT05360082

• Home-based brain stimulation for symptoms in Huntington's Disease

  This study is testing if a type of brain stimulation can help people with Huntington's Disease feel better by reducing symptoms like apathy, irritability, and depression.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT05326451

• Combined Thiamine and Biotin Treatment for Huntington's Disease

  This study is testing if a combination of thiamine and biotin can help slow down symptoms in people with mild to moderate Huntington's disease.

  Recruiting at 3 sites Phase 2 Fundación Pública Andaluza para la gestión de la Investigación en Sevilla · San Sebastián, San Sebastian and 2 other locations · NCT04478734

• Evaluating BDNF Biomarkers in Cerebrospinal Fluid for Huntington's Disease

  This study is testing if measuring a protein in the spinal fluid can help understand Huntington's Disease better and see how it relates to the disease's severity and brain changes.

  Recruiting University Hospital, Montpellier · Montpellier · NCT04012411

• Longitudinal imaging of brain changes in Huntington's disease

  This study looks at brain changes in people with Huntington's disease over three years to see how it progresses and to find possible signs that could help in future treatments.

  Recruiting King's College London · London, England · NCT03434548

• Evaluating retinal imaging for neurodegenerative diseases

  This study is testing if special eye scans can help spot early signs of neurodegenerative diseases like Alzheimer's and Parkinson's in people.

  Recruiting Duke University · Durham, North Carolina · NCT03233646

NIH-funded research (11)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Harnessing neuron-derived vesicles to find Huntington’s disease biomarkers

  A research project aims to identify brain-derived biomarkers in blood that reflect Huntington disease activity, using neuronal extracellular vesicles as the signal source.

  NIH research University of Central Florida · Orlando, United States · NIH-11448886

• Understanding how blood flow problems in the brain affect Huntington’s disease

  A study at a major hospital is looking at how blood vessels in the brain may contribute to symptoms and brain changes in Huntington’s disease.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11371125

• Rhes‑SUMO pathway's role in Huntington's disease

  This work looks at whether the Rhes‑SUMO protein system increases toxic huntingtin and helps it spread in the brain, which may explain early striatal damage in people with Huntington's disease.

  NIH research Florida Atlantic University · Boca Raton, United States · NIH-11299742

• Understanding how ribosome stalling affects Huntington disease

  This study is looking at how a problem with protein production in the brain might contribute to Huntington disease, which could help us find new ways to treat the condition.

  NIH research Florida Atlantic University · Boca Raton, United States · NIH-11264540

• Rhes-SUMO Pathway and Huntington Disease in Mice

  A study in mouse models explores how the Rhes-SUMO pathway may drive brain and nerve cell vulnerability in Huntington disease.

  NIH research Florida Atlantic University · Boca Raton, United States · NIH-11176921

• Investigating the role of the Rhes-SUMO pathway in Huntington's disease

  This study is looking at how a specific pathway in the brain might affect the worsening of Huntington's disease, with the hope of finding new ways to help manage the symptoms and slow down the disease for those living with it.

  NIH research University of Florida · Gainesville, United States · NIH-11175740

• Understanding how Huntington disease disrupts protein production in brain cells

  Researchers are studying Huntington disease to learn how a faulty protein blocks ribosomes and slows protein-making in brain cells, which may contribute to movement and thinking problems.

  NIH research Florida Atlantic University · Boca Raton, United States · NIH-11126038

• Investigating the role of the Rhes-SUMO pathway in Huntington's disease

  This study is looking at how a specific pathway in the brain might affect the progression of Huntington's disease, with the hope of finding new ways to help manage or treat the condition for patients.

  NIH research University of Florida · Gainesville, United States · NIH-10913474

• How Blood Vessel Changes in the Brain Affect Huntington's Disease

  This work explores how changes in brain blood vessels might contribute to the symptoms and progression of Huntington's disease in people living with the condition.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10912523

• Understanding behavior in youth at risk for Huntington disease

  This study is looking at the thinking and behavior challenges that young people at risk for Huntington disease might face, like trouble with decision-making, anxiety, and acting impulsively, to help find early signs and improve support for them before any physical symptoms appear.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10906848

• Investigating a new pathway in Huntington's disease

  This study is looking at how a specific pathway in the brain might affect nerve cell health in people with Huntington's disease, with the hope of finding new ways to help improve their condition.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-10851725

Related topics

Quick answers

How many Huntington Disease clinical trials are recruiting right now?

31, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 32 countries. The most sites are in United States (15 trials), France (8 trials), Belgium (5 trials), United Kingdom (5 trials), Germany (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1/2: 3, Phase 3: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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