Condition

Vascular Dementia clinical trials and research

• 14Clinical trials
• 23NIH research projects
• 7Countries

Newest Vascular Dementia clinical trials

All recruiting trials (14)

• Digital Dementia Registry Bavaria: a multicenter, long-term registry of people with mild cognitive impairment and dementia and their family caregivers

  This registry will collect long-term health and care data from people with mild cognitive impairment or dementia in Bavaria and their caregivers to understand how dementia progresses and how care is provided.

  Recruiting at 12 sites University of Erlangen-Nürnberg Medical School · Aschaffenburg and 11 other locations · NCT07721701

• Hyperspectral retinal imaging to detect Alzheimer’s and other neurodegenerative changes

  This project will test whether a special retinal camera that scans many wavelengths of light can detect signs of Alzheimer’s and other neurodegenerative diseases in people with dementia or at risk.

  Recruiting Center for Eye Research Australia · Melbourne, Victoria · NCT07545473

• What predicts emergency department visits in frail older adults

  This project tests whether a blood marker (plasma pTau181) and signs of cerebrovascular damage can help predict which non-autonomous older adults will need to return to the emergency department within six months.

  Recruiting University of Pisa · Pisa, Pisa · NCT07259499

• Analyzing the link between shingles and vascular dementia risk

  This study is trying to see if having shingles increases the risk of developing problems with blood vessels and vascular dementia compared to people who don't have shingles.

  Recruiting at 2 sites Center for Clinical Studies, Texas · Houston, Texas and 1 other locations · NCT06903078

• Pulsed electromagnetic field treatment for dementia patients

  This study is testing a pulsed electromagnetic device to see if it can help people with mild to moderate Alzheimer's disease improve their thinking and memory over 120 days.

  Recruiting Herrick Medical LLC · Boca Raton, Florida · NCT06862557

• Predicting disease progression in dementia using biomarkers and modeling

  This study is trying to create a tool that helps predict how dementia will progress in people with mild cognitive impairment and different types of dementia, like Alzheimer's and Lewy Body Disease, by looking at brain scans, body fluids, and mental tests.

  Recruiting University Health Network, Toronto · North York, Ontario and 3 other locations · NCT06529744

• Investigating retinal vessel leakage in cerebral small vessel disease

  This study is trying to see if leaking blood vessels in the eyes can help us understand how serious cerebral small vessel disease is in people who have had mild strokes.

  Recruiting University of Edinburgh · Edinburgh · NCT06416371

• BRAIN App program to support communication and engagement for people with dementia

  This program tests whether the BRAIN App can improve communication, mood, and quality of life for people aged 65 and older with dementia living in long-term care, with training and support for family members and staff.

  Recruiting Hopeful Aging · Winchester, Massachusetts · NCT06298474

• Investigating new blood tests for diagnosing memory disorders

  This study is testing new blood tests to see if they can help diagnose memory disorders like mild dementia and Alzheimer's better than the current method that uses spinal fluid.

  Recruiting Skane University Hospital · Malmö · NCT06122415

• Improving early diagnosis of dementia in primary care

  This study is trying to find better ways to diagnose Alzheimer's and other memory problems early in people visiting their primary care doctors.

  Recruiting Skane University Hospital · Malmö · NCT06120361

• Connecting Through Music for people with dementia

  The trial tests a music-based program led by volunteers or staff to help residents with dementia in long-term care facilities, aiming to ease behavioral symptoms and improve caregiving efficiency.

  Recruiting at 2 sites Hopeful Aging · Winchester, Massachusetts and 1 other locations · NCT06079216

• Examining cognitive and vascular functioning after traumatic brain injury

  This study is trying to see how brain injuries and heart health are connected to thinking problems in Service Members and Veterans.

  Recruiting Walter Reed National Military Medical Center · Bethesda, Maryland · NCT06034509

• Improving cognitive outcomes in patients with sleep apnea using home testing

  This study is trying to see if home testing for sleep apnea can help diagnose the condition better in people with cognitive issues like Alzheimer's, making it easier for them to get the treatment they need.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT04335994

• Online cognitive assessment for monitoring brain health

  This study is testing an online brain health test for people aged 50 and older to see if it can help track their thinking skills and identify any issues early on.

  Recruiting Alzheimer's Light LLC · Miami, Florida · NCT04114994

NIH-funded research (23)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• A brain-boosting peptide to help people at risk of vascular dementia and Alzheimer’s disease

  A new drug-like peptide (PNA5) is being studied to reduce brain inflammation and improve blood flow in people at risk for vascular dementia and Alzheimer's-related dementia.

  NIH research University of Arizona · Tucson, United States · NIH-11396379

• Cis-proline tau toxicity in brain injury and dementia

  Aims to understand how a specific toxic form of tau protein appears after brain injury and contributes to Alzheimer’s-related dementia, and how early intervention might protect neurons.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11386513

• Pathogenic exosomes in shingles and their link to vascular dementia

  A study explores how tiny particles shed during shingles may raise the risk of vascular dementia in people, with potential to inform prevention.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11380575

• Artery cell channels and stroke-related dementia in older men and women

  This work looks at whether blocking an artery-cell channel called Panx1 can help older men and women have less brain damage and dementia after an ischemic stroke.

  NIH research Tufts Medical Center · Boston, United States · NIH-11345816

• How blood vessel problems contribute to dementia

  Researchers are looking at how blood vessel problems in the heart and brain may lead to dementia in people with or at risk for Alzheimer’s.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11322624

• Scale-up of a peptide therapy to help brain blood flow and inflammation in people at risk for Alzheimer’s-related dementias

  A small US-based project will scale up manufacturing of a new peptide medicine (PNA5) intended to help people at risk for Alzheimer’s-related dementia and vascular dementia by improving brain blood flow and reducing inflammation.

  NIH research Proneurogen, INC. · Tucson, United States · NIH-11307341

• Exercise-Driven Repair of White Matter in Subcortical Vascular Dementia

  A new study at a major hospital will test whether exercise can boost the brain’s repair cells to help people with a form of dementia linked to blood vessels.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11243073

• Shingles-related blood particles that may raise vascular dementia risk

  This project looks at whether tiny blood particles released during shingles cause blood-vessel inflammation or clotting that can increase the chance of vascular dementia in older adults.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11195062

• Harmful tau protein changes after brain injury and vascular dementia

  This project will try blocking a harmful form of tau protein and boosting a protective neuron response to help people with traumatic brain injury or vascular-related dementia.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11173784

• Understanding gene control in vascular dementia

  This project looks at how special genetic signals called enhancer RNAs (eRNAs) might contribute to vascular dementia.

  NIH research University of South Florida · Tampa, United States · NIH-11171349

• Understanding how blood vessel problems contribute to vascular dementia

  This study is looking at how problems with blood vessels might lead to vascular dementia, a common cause of memory and thinking issues, and it aims to find new ways to help people with this condition by understanding the role of genetics and certain proteins in blood vessel health.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11169865

• PNA5 — a new Mas receptor medicine to protect thinking in people at risk for vascular and Alzheimer's-related dementia

  Seeing whether the anti-inflammatory peptide PNA5 can be safely developed to help people with mild cognitive impairment who are at risk for vascular dementia or Alzheimer's-related dementia.

  NIH research University of Arizona · Tucson, United States · NIH-11169018

• Investigating how a specific protein contributes to brain damage in Alzheimer's and related conditions

  This study is looking at how a specific form of a protein called cis P-tau might contribute to Alzheimer's disease and other brain issues, especially after injuries or reduced blood flow, to find new ways to protect brain cells and improve treatments for people affected by these conditions.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11142679

• Investigating how sex affects brain health in Alzheimer's and vascular dementia.

  This study is looking at how being male or female affects brain health in people with a family history of Alzheimer's disease and vascular dementia, and it aims to find ways to spot and treat these conditions earlier to help improve people's lives.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11129605

• Investigating myelin changes in aging and vascular dementia

  This study is looking at how getting older and having blood vessel problems can affect the protective covering of nerve fibers in the brain, which is important for thinking and memory, and it’s for anyone interested in understanding more about how these issues might relate to dementia and cognitive decline.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-11082427

• Investigating how protein changes affect brain health in sickle cell disease

  This study is looking at how sickle cell disease might be linked to memory and thinking problems, like those seen in vascular dementia, and it hopes to find new ways to help people with these conditions by understanding how certain proteins affect brain health.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11056649

• A new treatment for cognitive impairment related to vascular dementia and Alzheimer's disease

  This study is testing a new treatment called PNA5 that could help improve thinking and memory for people at risk of dementia by reducing inflammation and boosting blood flow to the brain, making sure it's safe before moving on to the next steps.

  NIH research University of Arizona · Tucson, United States · NIH-10910078

• Exploring how Perlecan affects blood vessels in vascular dementia

  This study is looking at how a protein called Perlecan affects blood vessels in the brain and how this might relate to memory problems in older adults with vascular dementia, with the hope of finding new ways to help improve brain health for those affected.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-10860279

• A protein linked to blood-flow-related memory loss in sickle cell disease

  This project looks at whether a protein called protein arginine methyltransferase (PRMT) causes blood-flow problems that lead to thinking and memory troubles in people with sickle cell disease.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-10829254

• Investigating how herpes zoster affects the risk of vascular dementia

  This study is looking at how shingles might be connected to a higher risk of developing vascular dementia, and it’s for anyone who has had shingles and wants to understand more about its potential long-term effects on brain health.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10806533

• Investigating the role of enhancer RNAs in vascular dementia

  This study is looking at how certain molecules called enhancer RNAs might play a role in the development of vascular dementia, using mice to mimic the effects of reduced blood flow to the brain, which could help us understand this condition better and find new ways to treat it.

  NIH research University of South Florida · Tampa, United States · NIH-10786221

• A new drug to treat vascular dementia

  This study is testing a new medication that could help reduce inflammation in the brain for people with vascular dementia, with the hope of slowing down the disease and improving thinking skills.

  NIH research University of Houston · Houston, United States · NIH-10726896

• Understanding how gene regulation affects brain cell recovery in vascular dementia

  This study is looking at how certain changes in our genes might help brain cells called oligodendrocytes heal and grow back, which could be really helpful for people with subcortical ischemic vascular dementia, a condition that affects thinking and memory.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10509535

Related topics

Quick answers

How many Vascular Dementia clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (6 trials), Canada (2 trials), Sweden (2 trials), United Kingdom (1 trial), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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