How C9ORF72 changes lead to frontotemporal dementia and ALS

Understanding Frontotemporal Dementia Using Drosophila and iPSC Models

NIH-funded research Univ of Massachusetts Med Sch Worcester · NIH-11307657

Researchers are using fruit flies and nerve cells made from patient samples to find genes that make C9ORF72-linked frontotemporal dementia or ALS better or worse.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniv of Massachusetts Med Sch Worcester NIH-funded
Lab location1 site (Worcester, United States)
Project IDNIH-11307657 on NIH RePORTER

What this research studies

This project uses classic fruit fly genetics alongside neurons grown from patient-derived induced pluripotent stem cells (iPSCs) to model disease caused by the G4C2 repeat expansion in C9ORF72. The team looks at toxic repeat RNAs and dipeptide repeat (DPR) proteins that appear in patient brains and screens for genetic modifiers that change disease signs. Findings from flies guide experiments in human neurons to confirm which molecular pathways drive neurotoxicity. The ultimate goal is to point to biological targets that could be tested as future therapies.

Who could benefit from this research

Good fit: Ideal participants would be people diagnosed with frontotemporal dementia or ALS who carry the C9ORF72 repeat expansion and are willing to provide a blood or skin sample for iPSC generation.

Not a fit: People without the C9ORF72 repeat expansion or with unrelated forms of dementia are unlikely to benefit directly from this work in the near term.

Why it matters

Potential benefit: If successful, the work could reveal molecular targets that lead to new therapies for patients with C9ORF72-linked frontotemporal dementia or ALS.

How similar studies have performed: Previous lab studies using flies and patient iPSC neurons have identified disease pathways and modifiers, but turning those findings into approved treatments remains early and ongoing.

Where this research is happening

Worcester, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Alzheimer disease dementiaAlzheimer syndromeAlzheimer's Disease
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.