Identifying molecular subtypes of emphysema using imaging and multi-omics data
Official title: Imaging and multi-omics analyses to identify molecular subtypes of distinct emphysema patterns
Funded at Brigham and Women's Hospital · NIH-10912814 · Data updated 2026-11-12
This study is looking at different types of emphysema to better understand the disease and find new ways to treat it, and it involves patients sharing blood and lung tissue samples along with imaging tests.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $880,542 |
| NIH project number | 5R01HL167072-02 |
| Project ID | NIH-10912814 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with emphysema or COPD, particularly those with distinct emphysema patterns.
✕Less likely to help
Patients without a diagnosis of emphysema or COPD are unlikely to benefit from this research.
What this research studies
This research investigates the different patterns of emphysema, a severe lung condition often associated with chronic obstructive pulmonary disease (COPD). By utilizing advanced imaging techniques and analyzing various biological data types, the study aims to uncover distinct molecular subtypes of emphysema. Patients will be involved in providing blood and lung tissue samples, which will be analyzed alongside imaging data to identify potential biomarkers and improve understanding of the disease. The ultimate goal is to enhance treatment strategies for individuals suffering from emphysema.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for patients with emphysema and COPD.
How similar studies have gone: Previous research has shown promise in using multi-omics approaches to understand complex diseases, suggesting potential for success in this novel application.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: El Boueiz, Adel — Brigham and Women's Hospital
- Study coordinator: El Boueiz, Adel
Related research
Other NIH-funded projects on the same topics.
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Precision phenotyping of emphysema in the elderly: a study in diverse adults
Researchers will look at CT scans and lung tests in older adults to understand different forms of emphysema and how they relate to health outcomes.
-
Lithium as a potential disease-modifying treatment for emphysema using a precision approach
A low-dose lithium approach is being studied to slow or modify emphysema in smokers who have COPD.
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Imaging and multi-omics to find subtypes of emphysema in COPD
This project looks for molecular subtypes of emphysema in COPD by combining imaging with blood and tissue data to improve understanding and treatment options.
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Precision phenotyping of emphysema in the elderly: the MESA Lung Study
Aging adults with or without COPD-related symptoms may benefit from a new study that maps subtypes of emphysema on CT scans to better predict health risks.
-
E-cigarette use and emphysema risk in young adults (VapeScan)
A study to understand whether vaping or traditional cigarettes cause early lung damage in young adults.
-
Loss of lung blood-vessel stem cells that may speed lung aging and raise emphysema risk
Researchers will look at how losing a type of lung blood-vessel progenitor cell may make lungs age faster and increase emphysema risk in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.