Investigating how specialized molecules help reduce inflammation in emphysema
Role of specialized pro-resolving mediators of inflammation resolution in emphysema: analyses of SPIROMICS and LEEP
This study is looking at how certain natural substances in the body can help reduce inflammation and improve lung health in people with emphysema, and it will track how these substances affect breathing and inflammation over time.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10972838 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specialized pro-resolving mediators (SPMs) in reducing inflammation in patients with emphysema. By analyzing data from the SPIROMICS cohort and the LEEP study, the researchers aim to determine if higher levels of SPMs in the blood are linked to better respiratory health outcomes. The study will explore how these mediators can potentially enhance the body's natural ability to resolve inflammation, which is crucial for managing chronic lung diseases. Patients will be monitored for their inflammatory responses and respiratory function over the course of the study.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with emphysema or chronic obstructive pulmonary disease (COPD).
Not a fit: Patients without a diagnosis of emphysema or COPD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve lung health and quality of life for patients with emphysema.
How similar studies have performed: Previous research has shown promising results regarding the role of specialized pro-resolving mediators in other inflammatory conditions, suggesting potential for success in this area as well.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Bose, Sonali — Icahn School of Medicine at Mount Sinai
- Study coordinator: Bose, Sonali
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.