Investigating how specialized molecules help reduce inflammation in emphysema
Official title: Role of specialized pro-resolving mediators of inflammation resolution in emphysema: analyses of SPIROMICS and LEEP
Funded at Icahn School of Medicine at Mount Sinai · NIH-10972838 · Data updated 2026-11-12
This study is looking at how certain natural substances in the body can help reduce inflammation and improve lung health in people with emphysema, and it will track how these substances affect breathing and inflammation over time.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $139,088 |
| NIH project number | 1R21HL175177-01 |
| Project ID | NIH-10972838 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with emphysema or chronic obstructive pulmonary disease (COPD).
✕Less likely to help
Patients without a diagnosis of emphysema or COPD may not benefit from this research.
What this research studies
This research focuses on understanding the role of specialized pro-resolving mediators (SPMs) in reducing inflammation in patients with emphysema. By analyzing data from the SPIROMICS cohort and the LEEP study, the researchers aim to determine if higher levels of SPMs in the blood are linked to better respiratory health outcomes. The study will explore how these mediators can potentially enhance the body's natural ability to resolve inflammation, which is crucial for managing chronic lung diseases. Patients will be monitored for their inflammatory responses and respiratory function over the course of the study.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve lung health and quality of life for patients with emphysema.
How similar studies have gone: Previous research has shown promising results regarding the role of specialized pro-resolving mediators in other inflammatory conditions, suggesting potential for success in this area as well.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Bose, Sonali — Icahn School of Medicine at Mount Sinai
- Study coordinator: Bose, Sonali
Related research
Other NIH-funded projects on the same topics.
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Precision phenotyping of emphysema in the elderly: a study in diverse adults
Researchers will look at CT scans and lung tests in older adults to understand different forms of emphysema and how they relate to health outcomes.
-
Lithium as a potential disease-modifying treatment for emphysema using a precision approach
A low-dose lithium approach is being studied to slow or modify emphysema in smokers who have COPD.
-
Imaging and multi-omics to find subtypes of emphysema in COPD
This project looks for molecular subtypes of emphysema in COPD by combining imaging with blood and tissue data to improve understanding and treatment options.
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Precision phenotyping of emphysema in the elderly: the MESA Lung Study
Aging adults with or without COPD-related symptoms may benefit from a new study that maps subtypes of emphysema on CT scans to better predict health risks.
-
E-cigarette use and emphysema risk in young adults (VapeScan)
A study to understand whether vaping or traditional cigarettes cause early lung damage in young adults.
-
Loss of lung blood-vessel stem cells that may speed lung aging and raise emphysema risk
Researchers will look at how losing a type of lung blood-vessel progenitor cell may make lungs age faster and increase emphysema risk in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.