Investigating B cells in patients with emphysema-predominant COPD
B cell-adaptive Immune Profile in Emphysema-predominant COPD
This study is looking at how a type of immune cell called B cells acts in people with emphysema, a form of chronic lung disease, to see how these changes might be linked to lung damage, and it involves analyzing samples from patients to better understand what's happening in their lungs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10906676 on NIH RePORTER |
What this research studies
This research focuses on understanding how B cells, a type of immune cell, behave in patients with emphysema-predominant chronic obstructive pulmonary disease (COPD). The study aims to identify specific changes in the B cell profile and their relationship to lung damage. Researchers will analyze lung tissue and blood samples from COPD patients to assess B cell activity and characteristics, using advanced techniques like immunostaining and next-generation sequencing. By comparing patients with varying degrees of emphysema, the research seeks to uncover the underlying mechanisms that contribute to lung destruction in these individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with emphysema-predominant COPD, regardless of the severity of their airflow limitation.
Not a fit: Patients with COPD who do not have emphysema may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting B cells to improve outcomes for patients with emphysema-predominant COPD.
How similar studies have performed: Other research has shown promising results in understanding immune responses in COPD, making this approach both relevant and potentially impactful.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Polverino, Francesca — Baylor College of Medicine
- Study coordinator: Polverino, Francesca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.