Using doxycycline to slow emphysema in people with HIV
1/2 Doxycycline for Emphysema in People Living with HIV: The DEPTH Trial
The DEPTH trial is looking at whether the antibiotic doxycycline can help slow down emphysema in people with well-controlled HIV who are current or former smokers, and you'll either get doxycycline or a placebo for 72 weeks to see how it affects your lung function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10911918 on NIH RePORTER |
What this research studies
The DEPTH trial investigates the use of doxycycline, an antibiotic, to slow the progression of emphysema in individuals living with HIV. This phase II trial will involve participants who are current or former smokers and have well-controlled HIV. Participants will be randomly assigned to receive either doxycycline or a placebo for 72 weeks, with the primary goal of measuring changes in lung function. The study aims to target specific biological markers associated with emphysema progression in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults living with HIV who have been diagnosed with emphysema and are current or former smokers.
Not a fit: Patients who do not have emphysema or those with uncontrolled HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new therapeutic option to slow down emphysema progression in people living with HIV.
How similar studies have performed: Previous studies have shown the feasibility of targeting matrix metalloproteinases in HIV-positive individuals with emphysema, indicating potential for success in this approach.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Kaner, Robert J — Weill Medical Coll of Cornell Univ
- Study coordinator: Kaner, Robert J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.