How immune cells affect lung stem cells in emphysema
Suppression of alveolar stem cells by tissue-resident lymphocytes in emphysema
This study is looking at how certain immune cells in the lungs affect the healing stem cells in people with emphysema, aiming to find new ways to help improve lung health and prevent flare-ups.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11024845 on NIH RePORTER |
What this research studies
This research investigates the role of tissue-resident lymphocytes in the suppression of alveolar stem cells in patients with emphysema, a severe form of chronic obstructive pulmonary disease (COPD). The study aims to understand how viral infections trigger inflammation in the lungs, leading to the loss of these important stem cells that help maintain lung structure and function. By examining the interactions between immune cells and lung tissue, the researchers hope to uncover new therapeutic strategies to prevent exacerbations and improve lung health in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with emphysema or chronic obstructive pulmonary disease (COPD).
Not a fit: Patients without a diagnosis of emphysema or those with other unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung function and reduce the frequency of acute exacerbations in emphysema patients.
How similar studies have performed: Previous research has shown promising results in understanding the immune response in lung diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Peng, Tien — University of California, San Francisco
- Study coordinator: Peng, Tien
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.