Understanding How Smoking Causes Different Types of Lung Damage
Official title: Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers
Funded at Weill Medical Coll of Cornell Univ · NIH-11177656 · Data updated 2026-11-12
This research helps us understand why cigarette smoking can lead to different serious lung conditions like emphysema or lung scarring.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 6, 2013 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $2,543,097 |
| NIH project number | 5P01HL114501-10 |
| Project ID | NIH-11177656 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is for anyone interested in the mechanisms of lung disease caused by smoking, particularly those with or at risk for emphysema or idiopathic pulmonary fibrosis.
✕Less likely to help
Patients seeking immediate new treatments or direct clinical intervention would not directly benefit from this basic and translational science project.
What this research studies
Our team of experts is working to uncover the specific ways cigarette smoke harms the lungs, leading to either emphysema or a scarring condition called fibrosis. We use different approaches, including studying cells in the lab and using animal models to see how these diseases develop. We also look at human lung tissues and cells to find new clues about the genetic and biological changes that happen. This combined effort helps us get a clearer picture of these complex lung diseases, bringing together basic, translational, and clinical researchers.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat lung diseases caused by smoking, offering hope for better health outcomes.
How similar studies have gone: This project builds upon several years of successful prior funding, integrating expertise from various fields to tackle this complex challenge.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Choi, Mary E — Weill Medical Coll of Cornell Univ
- Study coordinator: Choi, Mary E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.