Condition

Alpha1-Antitrypsin Deficiency clinical trials and research

• 4Clinical trials
• 19Countries

Newest Alpha1-Antitrypsin Deficiency clinical trials

All recruiting trials (4)

• Testing CE1226 doses to slow lung disease in adults with alpha-1 antitrypsin deficiency

  This trial tests two active doses of CE1226 to see if they slow lung density decline in adults with AAT deficiency and emphysema over 3 years compared with the standard 60 mg/kg dose.

  Recruiting at 2 sites Phase 4 CSL Behring · Aalborg and 1 other locations · NCT07326592

• Understanding liver problems in adults with Alpha-1 Antitrypsin Deficiency

  This study looks at how liver problems develop over time in adults with Alpha-1 Antitrypsin Deficiency to better understand their health and improve treatment options.

  Recruiting at 8 sites Takeda · Gainesville, Florida and 7 other locations · NCT06512454

• Investigating the safety and effects of Fazirsiran for liver disease caused by Alpha-1 Antitrypsin Deficiency

  This study is testing a new medication called Fazirsiran to see if it can safely help people with liver disease caused by Alpha-1 Antitrypsin Deficiency by reducing a harmful protein.

  Recruiting at 40 sites Phase 3 Takeda · Phoenix, Arizona and 40 other locations · NCT06165341

• Evaluating the safety and effectiveness of fazirsiran for liver disease caused by an abnormal protein.

  This study is testing if a new drug called fazirsiran can help reduce liver scarring in people with Alpha-1 Antitrypsin Deficiency.

  Recruiting at 81 sites Phase 3 Takeda · Birmingham, Alabama and 88 other locations · NCT05677971

Related topics

Quick answers

How many Alpha1-Antitrypsin Deficiency clinical trials are recruiting right now?

4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 19 countries. The most sites are in Austria (3 trials), Germany (3 trials), Spain (3 trials), United Kingdom (3 trials), United States (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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