Identifying brain networks involved in drug-resistant epilepsy
Establishing novel properties of dynamic systems models to identify epileptogenic networks in patients with drug resistant epilepsy
This study is looking to help people with drug-resistant epilepsy by finding out exactly where in the brain their seizures come from, using advanced technology to analyze brain activity, which could lead to better surgery results for those who need it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11017819 on NIH RePORTER |
What this research studies
This research focuses on patients with drug-resistant epilepsy, aiming to improve the identification of the brain regions responsible for seizures. By utilizing advanced dynamic systems models and analyzing intracranial EEG data, the project seeks to uncover patterns and biomarkers that can help localize the epileptogenic zone more effectively. This could lead to better surgical outcomes for patients who are candidates for epilepsy surgery, as it aims to enhance the precision of identifying the areas of the brain that need to be targeted. The methodology involves extensive data collection and analysis, including imaging and EEG recordings, to ensure a comprehensive understanding of the patient's condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with drug-resistant epilepsy who have not responded to conventional anti-epileptic medications.
Not a fit: Patients with epilepsy that is well-controlled by medication or those who are not candidates for surgical intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve surgical outcomes for patients with drug-resistant epilepsy, potentially leading to seizure freedom.
How similar studies have performed: Previous research has shown promise in using advanced EEG analysis techniques to improve seizure localization, indicating that this approach could yield significant advancements.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Sarma, Sridevi V. — Johns Hopkins University
- Study coordinator: Sarma, Sridevi V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.