Closed-loop implant to target seizure-related high-frequency brain waves in drug-resistant epilepsy
Acute Modulation of Stereotyped High Frequency Oscillations with a Closed-Loop Brain Interchange System in Drug Resistant Epilepsy
An implantable device will try to find and interrupt seizure-related high-frequency brain waves in people whose seizures don't respond to medicines.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11097353 on NIH RePORTER |
What this research studies
You would get a small implanted Brain Interchange device that continuously records high-frequency brain signals (iEEG) from areas suspected to start seizures. Researchers will look for repeated, stereotyped high-frequency oscillation (HFO) waveforms that their earlier work found in seizure-onset zones and compare them to irregular HFOs from non-seizure areas. When the device detects those stereotyped HFOs, it would deliver brief stimulation to interrupt the abnormal activity in a closed-loop way. The team will track recordings, stimulation events, and clinical seizure outcomes to see if the implant can safely capture and modulate these seizure-related signals.
Who could benefit from this research
Good fit: Adults with drug-resistant focal epilepsy who are candidates for intracranial monitoring or an implantable neurostimulation system would be the ideal participants.
Not a fit: People whose seizures are well controlled with medication, those with primarily generalized epilepsy, or anyone who cannot undergo brain implantation or surgery are unlikely to benefit.
Why it matters
Potential benefit: If successful, the device could better target and interrupt seizure-generating brain activity and reduce seizures for people with drug-resistant epilepsy.
How similar studies have performed: Previous studies show HFOs can mark seizure onset zones and closed-loop stimulation can lower seizures, but using stereotyped HFO waveforms with an implantable Brain Interchange system is a novel, early approach.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Ince, Nuri Firat — Mayo Clinic Rochester
- Study coordinator: Ince, Nuri Firat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.