Mapping social cognition in epilepsy patients
Official title: Cartography of Social Cognition Network and Their Alterations in Patients With Epilepsy
Run by Assistance Publique - Hôpitaux de Paris · NCT05527093 · Data updated 2026-11-12
This study is trying to see how epilepsy affects social thinking by comparing brain scans and tests of social skills in people with epilepsy and healthy individuals before and after surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 2 sites (Gif-sur-Yvette and 1 other locations) |
| Status | Recruiting |
| Started | March 19, 2025 |
| Main results expected | January 19, 2029 |
| Study ends | January 19, 2029 |
| Registry record updated | March 21, 2025 |
| Trial ID | NCT05527093 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with drug-resistant focal temporal lobe epilepsy due to hippocampal sclerosis.
✕Probably not a fit
Patients with conditions that contraindicate MRI or those under juridical protection may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to explore the social cognition network in patients with drug-resistant medial temporal lobe epilepsy and healthy individuals. It will assess social cognition deficiencies using a validated neuropsychological assessment and perform brain structural analyses with advanced MRI techniques. The research will involve 20 healthy subjects and 20 epilepsy patients, evaluating them before and one year after surgical intervention. The goal is to better understand the brain alterations associated with social cognition deficits in epilepsy.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment of social cognition deficits in epilepsy patients, enhancing their quality of life.
How similar studies have gone: While studies have explored aspects of social cognition in epilepsy, this comprehensive mapping approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * Age ≥ 18 years old * Good understanding of written and verbal French language * Written consent signed by the subject * Patients with focal temporal lobe epilepsy for at least one year, drug-resistant, due to a hippocampal sclerosis * Undergoing presurgical assessment * Affiliated to a social security system Exclusion criteria: * Under juridical protection * With claustrophobia or any MRI contra-indication * Pregnancy or lactation * Participation in another research with an exclusion period * Refusal to be notified in the event of anomalies discovered during the performance of an MRI sequence
Where it's running
-
Unité d'épilepsie - GHU Pitié Salpêtrière
Paris, France Recruiting -
NeuroSpin - CEA
Gif-sur-Yvette, France Active not recruiting
Study contacts
- Study coordinator: Bastien HERLIN, MD, PH
- Email: bastien.herlin@php.fr
- Phone: 1 42 16 03 01
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy
This study tests whether low intensity focused ultrasound can help reduce seizures in adults with drug‑resistant epilepsy.
-
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This uses a PET‑MRI scan with the tracer [18F]MPPF to see if serotonin pathways in the brainstem differ in adults with Dravet syndrome compared with healthy controls.
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This project will see if gut bacteria and their chemical products are linked to how well people with new‑onset or drug‑resistant epilepsy do after surgery, vagus‑nerve stimulation, or a ketogenic diet.
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Evaluating a new ultrasound treatment for drug-resistant epilepsy
This study is testing a new ultrasound treatment for people with drug-resistant epilepsy to see if it can help reduce their seizures and improve their quality of life.
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Low-intensity focused ultrasound treatment for drug-resistant epilepsy
This study is testing if low-intensity focused ultrasound can help people with drug-resistant temporal lobe epilepsy have fewer seizures while they continue taking their regular medications.
-
Personalized electrical stimulation for drug-resistant epilepsy
This study is testing if a personalized electrical stimulation treatment can help people with drug-resistant epilepsy have fewer seizures and improve their quality of life.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.