Comparing MEG and EEG for locating the source of epilepsy before surgery
MEG Versus EEG HR for the Localization of the Epileptogenic Zone as Part of the Pre-surgical Assessment of Epilepsy
NA · Hospices Civils de Lyon · NCT03893916
This study is testing whether a new brain scanning method called MEG works better than a traditional method called EEG to find the source of seizures in people with epilepsy who might need surgery.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Hospices Civils de Lyon (other) |
| Locations | 1 site (Bron) |
| Trial ID | NCT03893916 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of MagnetoEncephalography (MEG) versus high-resolution Electroencephalography (EEG HR) in identifying the epileptogenic zone in patients with drug-resistant partial epilepsy. Participants will undergo both MEG and EEG HR to determine which method provides better localization of the brain area responsible for seizures. The findings aim to enhance pre-surgical assessments and improve surgical outcomes for epilepsy patients. The study focuses on patients who are candidates for surgical intervention based on their epilepsy condition.
Who should consider this trial
Good fit: Ideal candidates are patients aged 18 to 60 with drug-resistant partial epilepsy who are scheduled for surgical evaluation.
Not a fit: Patients over 60, under 18, or those with contraindications to brain MRI and MEG will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate localization of seizure sources, improving surgical outcomes for epilepsy patients.
How similar studies have performed: Previous studies have indicated that both MEG and EEG HR have unique advantages in localizing seizure sources, suggesting potential for success in this comparative approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients with partial epilepsy for at least 2 years and for whom are decided and planned: either i) a surgical procedure to resect the epileptogenic zone without prior intracranial EEG recording either ii) an intracranial EEG record needed before a possible cortectomy procedure * Routine scalp EEG revealing known paroxysmal interictal abnormalities (at least 5 points on a 20-minute plot performed less than 2 years before inclusion in the study) * Patient giving written consent Exclusion Criteria: * patient aged over 60 or under 18 * patients with contraindications to brain MRI and MEG * women of childbearing age for whom a urine pregnancy test performed during the first visit would detect a pregnancy
Where this trial is running
Bron
- Hospices Civils de Lyon — Bron, France (RECRUITING)
Study contacts
- Study coordinator: Julien JUNG, Dr
- Email: julien.jung@chu-lyon.fr
- Phone: 04 72 35 79 00
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Drug-resistant Epilepsy, Candidates for Surgical Treatment, Epilepsy