Improving MRI for identifying networks in drug-resistant epilepsy
Epileptogenic Network Visualisation With Advanced MRI
This study is testing new MRI techniques to see if they can better identify the brain networks causing seizures in people with drug-resistant epilepsy.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 3 Years and up |
| Sex | All |
| Sponsor | Cliniques universitaires Saint-Luc- Université Catholique de Louvain Academic / other |
| Locations | 1 site (Brussels) |
| Trial ID | NCT06059157 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to enhance the non-invasive identification of epileptogenic networks in patients with drug-resistant epilepsy. It compares the accuracy of network identification using advanced MRI techniques against the gold standard of stereo-EEG. Participants, already selected for stereo-EEG, will undergo an additional MRI with various sequences to analyze the epileptogenic networks. The study will also evaluate the evolution of these networks after therapeutic surgery through follow-up MRIs.
Who should consider this trial
Good fit: Ideal candidates are patients suffering from drug-resistant epilepsy who have already been selected for stereo-EEG implantation.
Not a fit: Patients who are excluded from stereo-EEG or have contraindications for MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate identification of epileptogenic networks, improving treatment outcomes for patients with drug-resistant epilepsy.
How similar studies have performed: Other studies have shown promise in using advanced imaging techniques for similar purposes, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient suffering from drug-resistant epilepsy * Patient already selected for SEEG implantation as part of their epileptic networks Exclusion Criteria: * Patient excluded from SEEG (pregnant women, children too young for the procedure, patient unable to undergo the procedure) * Contra-indication for MRI
Where this trial is running
Brussels
- Cliniques Universitaires St-Luc — Brussels, Belgium (Recruiting)
Study contacts
- Principal investigator: Riëm El Tahry, PhD — Cliniques universitaires Saint-Luc- Université Catholique de Louvain
- Study coordinator: Riëm El Tahry, PhD
- Email: riem.eltahry@saintluc.uclouvain.be
- Phone: 003227641080
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.