Exploring brain areas causing drug-resistant epilepsy using advanced imaging techniques

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the characteristics of epileptogenic foci in patients suffering from drug-resistant epilepsy by utilizing multimodal imaging technology. It will prospectively recruit 50 patients aged 18 and older from the Epilepsy Center at Xijing Hospital, collecting clinical baseline data and imaging results. The study will analyze these data to identify key network nodes that may assist in diagnosing drug-resistant epilepsy more effectively.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged ≥18 years old;
2. Meet the 2010 International League Against Epilepsy (ILAE) diagnostic criteria for drug-resistant epilepsy;
3. Duration of epilepsy ≥2 years, with an average seizure frequency of ≥2 times per month in the 3 months prior to enrollment;
4. Adequate intake of two or more anti-epileptic drugs, with no intervention in the treatment plan during the trial period;
5. Capable of cooperating to complete treatment and related examination items; The patient and family fully understand and voluntarily sign the informed consent form.

Exclusion Criteria:

1. In a state of continuous epileptic seizures;
2. Complicated with severe infections, cerebrovascular diseases, malignant tumors, and other diseases, accompanied by severe dysfunction of the heart, liver, kidney, or other organs, or with mental disorders, or with uncorrectable hyperglycemia, or 3.patients on long-term use of corticosteroid medications;

4.Pregnant or lactating women; 5.Contraindications for PET, MR, EEG examinations; 6.Patients with examinations (with ferromagnetic metal implants in the body; high fever); 7.Participating in other clinical trials at the same time; 8.The patient or family withdraws the informed consent form.

Where it's running

• Xijing Hospital of Air Force Military Medical University
  Xi'an, China Recruiting

Study contacts

• Study coordinator: Guan Xiao
• Email: guanxiao0223@163.com
• Phone: 18392320919

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.