Understanding brain cell changes in children with drug-resistant epilepsy
Deciphering brain mosaicism in drug-resistant epilepsy at cellular resolution
This study is looking at how certain changes in brain cells might cause epilepsy in children that doesn't respond to usual treatments, with the hope of finding better ways to diagnose and treat these kids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-11004033 on NIH RePORTER |
What this research studies
This research investigates the complex changes in brain cells that contribute to drug-resistant epilepsy in children. By focusing on somatic mosaicism, which involves genetic variations in specific brain cells, the study aims to improve detection methods for these variants and understand their effects on brain function. The researchers will analyze how these genetic changes occur in different cell types and their implications for developing targeted therapies. Ultimately, the goal is to translate these findings into better diagnostic and treatment options for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have been diagnosed with drug-resistant epilepsy.
Not a fit: Patients who do not have epilepsy or whose condition is not related to malformations of cortical development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for children suffering from drug-resistant epilepsy.
How similar studies have performed: Previous research has shown promise in understanding somatic mosaicism and its implications for neurological conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Bedrosian, Tracy Ann — Research Inst Nationwide Children's Hosp
- Study coordinator: Bedrosian, Tracy Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.