Understanding Inhibitory Neurotransmission in Drug-Resistant Epilepsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the functional alterations of GABA-A receptors in patients with drug-resistant temporal lobe epilepsy. The researchers will utilize patch-clamp recordings to characterize GABA-A mediated currents and identify the receptor subunit composition. Additionally, the study will explore the modulation of inhibitory neurotransmission through selective neuroactive molecules to enhance GABA release in the epileptic brain. The ultimate goal is to gain insights that could lead to new therapeutic strategies for managing epilepsy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients with drug-resistant temporal lobe epilepsy.

Exclusion Criteria:

* Patients suffering from Temporal lobe epilepsy caused by stroke, ischemia, cavernous angiomas, or meningiomas growth.

Where it's running

• IRCCS INM Neuromed
  Pozzilli, Isernia, Italy Recruiting

Study contacts

• Principal investigator: katiuscia Martinello, Biology — Neuromed IRCCS
• Study coordinator: katiuscia Martinello, Biology
• Email: katiuscia.martinello@neuromed.it
• Phone: 0865915218

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Overnight Temporal Interference Stimulation for Temporal Lobe Epilepsy

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• Biomarkers of Response to SEEG Thermocoagulation

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  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT07399327

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.