Condition

KRAS G12D clinical trials and research

• 5Clinical trials
• 10Countries

Newest KRAS G12D clinical trials

All recruiting trials (5)

• BBO-11818 treatment for adults with KRAS mutant cancer

  This study is testing a new drug called BBO-11818 to see if it can help adults with certain types of cancer that have specific KRAS mutations.

  Recruiting at 17 sites Phase 1 TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) · Los Angeles, California and 16 other locations · NCT06917079

• RE002 T‑cell injection for KRAS G12D mutated solid tumors

  This trial tests whether a personalized RE002 T‑cell infusion is safe and can shrink tumors in adults with advanced solid tumors that have a KRAS G12D mutation and are HLA‑A*11:01 positive.

  Recruiting Phase 1 Henan Cancer Hospital · Zhengzhou, Henan · NCT06546150

• T cell therapy targeting KRAS G12D in advanced solid tumors

  This trial will test whether autologous T cells engineered to recognize KRAS G12D can help adults with unresectable or metastatic solid tumors who have the matching HLA type.

  Recruiting at 18 sites Phase 1 AstraZeneca · Duarte, California and 17 other locations · NCT06218914

• Targeted therapies for patients with vascular malformations

  This study is testing new targeted treatments for patients with slow-flow and fast-flow vascular malformations to see if they work better than the usual therapies.

  Recruiting at 2 sites Phase 2 Murdoch Childrens Research Institute · Parkville, Victoria and 1 other locations · NCT05983159

• Evaluating BDTX-4933 for patients with specific cancer mutations

  This study is testing a new drug called BDTX-4933 to see if it can help adults with advanced cancers that have certain gene mutations feel better and improve their treatment options.

  Recruiting at 34 sites Phase 1/2 Servier · Gilbert, Arizona and 48 other locations · NCT05786924

Related topics

Quick answers

How many KRAS G12D clinical trials are recruiting right now?

5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in Australia (3 trials), United States (3 trials), China (2 trials), Denmark (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3, Phase 1/2: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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