p16 protein expression in colorectal cancer and its links to clinical and pathological features

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project will use 50 archived colorectal cancer tissue blocks from the Pathology Department of Sohag University Hospital. Hematoxylin and eosin sections will confirm diagnosis, histopathological type, grade, and stage, and additional sections will be stained by immunohistochemistry for p16. Investigators will score p16 positivity, staining intensity, and distribution and correlate these measures with patients' age, sex, tumor location, histologic phenotype, nodal involvement, perineural invasion, and lymphovascular invasion. No interventions are given to patients; the work analyzes existing formalin-fixed, paraffin-embedded specimens with linked clinical data.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Specimens from patients with colorectal cancer.
2. Tissue blocks with sufficient material.
3. Specimens with sufficient clinical data.

Exclusion Criteria:

1. Tissue blocks with insufficient, destroyed or necrotic material.
2. Specimens with insufficient clinical data.

Where it's running

• Faculty of Medicine
  Sohag, Recruiting, Egypt Recruiting

Study contacts

• Study coordinator: Sherry R Azmy, Demonstrator of pathology
• Email: shery.raoof@med.sohag.edu.eg
• Phone: 01507557371

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.