Condition

Familial Adenomatous Polyposis clinical trials and research

• 12Clinical trials
• 1NIH research projects
• 6Countries

Newest Familial Adenomatous Polyposis clinical trials

All recruiting trials (12)

• Classifying duodenal polyps in familial adenomatous polyposis

  This project will test two risk models to see if they better predict dangerous duodenal polyps and cancer risk in people with genetically confirmed FAP.

  Recruiting at 2 sites Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Milan, MI and 1 other locations · NCT07199127

• Personalized home treadmill exercise for people with Familial Adenomatous Polyposis (FAP)

  This trial will try different amounts of home treadmill exercise in people with FAP who have at least five rectal polyps to see if exercise can help prevent polyps from coming back.

  Recruiting University of Michigan Rogel Cancer Center · Ann Arbor, Michigan and 1 other locations · NCT06641310

• Investigating factors that influence polyp development in patients with Familial Adenomatous Polyposis

  This study looks at how gut bacteria and environmental factors might affect polyp growth in people with Familial Adenomatous Polyposis who have had preventive surgery and regular check-ups.

  Recruiting at 2 sites Hospices Civils de Lyon · Lyon, France and 1 other locations · NCT06614738

• TPST-1495 treatment for people with familial adenomatous polyposis

  This trial will try an oral drug called TPST-1495 to see if it reduces the number of polyps in the small bowel and colon in people with familial adenomatous polyposis.

  Recruiting at 2 sites Phase 2 National Cancer Institute (NCI) · Phoenix, Arizona and 3 other locations · NCT06557733

• 10 cm versus 15 cm J-shaped ileal pouch after IPAA surgery

  This trial will see if a 10 cm or a 15 cm J-pouch gives better bowel function and quality of life for people having IPAA for ulcerative colitis or familial adenomatous polyposis.

  Recruiting at 2 sites Odense University Hospital · Aarhus and 1 other locations · NCT06538402

• ONC201 (dordaviprone) for safety and prevention of colorectal polyps in high-risk adults.

  This trial tests whether different doses of ONC201 (dordaviprone) are safe and can help prevent new colorectal polyps in adults with familial adenomatous polyposis or a history of multiple adenomas.

  Recruiting at 3 sites Phase 1 National Cancer Institute (NCI) · Ann Arbor, Michigan and 4 other locations · NCT05630794

• Evaluating REC-4881 for treating Familial Adenomatous Polyposis

  This study is testing a new drug called REC-4881 to see if it can help people with Familial Adenomatous Polyposis feel better after their surgery.

  Recruiting at 7 sites Phase 1/2 Recursion Pharmaceuticals Inc. · Scottsdale, Arizona and 16 other locations · NCT05552755

• Personalized care for patients with Familial Adenomatous Polyposis after surgery

  This study is testing a personalized follow-up plan for people with familial adenomatous polyposis who have had surgery to see if it helps prevent cancer and manage their health better.

  Recruiting at 2 sites Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Houston, Texas and 1 other locations · NCT04678011

• Personalized care for patients with familial adenomatous polyposis

  This study is testing a personalized care plan for people with familial adenomatous polyposis to see if it can better manage their duodenal and gastric polyps and reduce the need for surgery.

  Recruiting at 2 sites Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Houston, Texas and 1 other locations · NCT04677998

• Cold snare polypectomy for duodenal adenomas in patients with Familial Adenomatous Polyposis

  This study is testing whether a method called cold snare polypectomy is effective for removing duodenal adenomas in patients with Familial Adenomatous Polyposis.

  Recruiting Western Sydney Local Health District · Westmead, New South Wales · NCT03471403

• Investigating genetic factors in childhood cancer

  This study is trying to find out if certain genes passed down in families can increase the risk of childhood cancer by looking at samples from kids who have had cancer and their relatives.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT03050268

• A resource for collecting cancer data and biospecimens

  This study is creating a resource to collect health information and samples from cancer patients and healthy individuals to help improve cancer prevention and treatment strategies.

  Recruiting at 42 sites University of Nebraska · Greenwood Village, Colorado and 41 other locations · NCT02012699

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Using IL-10NanoCap® to treat Familial Adenomatous Polyposis

  This study is testing a new oral treatment called FAPXIL for people with Familial Adenomatous Polyposis (FAP) to see if it can help manage polyps and lower the risk of colon cancer, and it could offer a new option for patients looking for better ways to handle their condition.

  NIH research Therapyx, INC. · Buffalo, United States · NIH-11061252

Related topics

Quick answers

How many Familial Adenomatous Polyposis clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (8 trials), Netherlands (2 trials), Australia (1 trial), France (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Phase 1: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →