Understanding how RNA communication affects colorectal cancer
Official title: exRNA in colorectal carcinoma: biogenesis and function
Funded at Vanderbilt University · NIH-10759428 · Data updated 2026-11-12
This study is looking at how tiny pieces of RNA found outside of cells might affect the growth and spread of colorectal cancer, with the hope that understanding this could lead to new treatments for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | January 22, 2020 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,691,857 |
| NIH project number | 5P01CA229123-05 |
| Project ID | NIH-10759428 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with colorectal carcinoma who are interested in contributing to advancements in cancer treatment.
✕Less likely to help
Patients with other types of cancer or those not diagnosed with colorectal carcinoma may not receive direct benefits from this research.
What this research studies
This research investigates the role of extracellular RNA (exRNA) in colorectal carcinoma, focusing on how these molecules influence cancer development and progression. The study aims to uncover the mechanisms by which exRNAs are packaged and transferred between cells, particularly through extracellular vesicles (EVs). By examining different aspects of RNA communication, the research seeks to identify key factors that could impact gene expression and cellular behavior in colorectal cancer. Patients may benefit from insights that could lead to new therapeutic strategies targeting these communication pathways.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that disrupt harmful RNA communication in colorectal cancer.
How similar studies have gone: Other research has shown promising results in understanding RNA communication in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Weaver, Alissa M — Vanderbilt University
- Study coordinator: Weaver, Alissa M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.